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Literature summary for 1.1.1.38 extracted from

  • Iwakura, M.; Tokushige, M.; Katsuki, H.; Muramatsu, S.
    Studies on regulatory functions of malic enzymes. V. Comparative studies of malic enzymes in bacteria (1978), J. Biochem., 83, 1387-1394.
    View publication on PubMed
Search for more literature for 1.1.1.38

Activating Compound

Activating Compound Comment Organism Structure
aspartate 0.005 mM, 15% activation Escherichia coli W
aspartate 0.005 mM, 18% activation Citrobacter freundii
aspartate 0.005 mM, 20% activation Erwinia aroidea
aspartate 0.005 mM, 20% activation Escherichia coli K-12
aspartate 0.005 mM, 20% activation Escherichia coli B
aspartate 0.005 mM, 35% activation Proteus vulgaris

Inhibitors

Inhibitors Comment Organism Structure
succinate 0.005 mM, slight inhibition Citrobacter freundii
succinate 0.005 mM, slight inhibition Escherichia coli B
succinate 0.005 mM, slight inhibition Escherichia coli K-12
succinate 0.005 mM, slight inhibition Escherichia coli W
succinate 0.005 mM, slight inhibition Klebsiella aerogenes

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.4
-
 L-malate
-
 Proteus vulgaris
0.5
-
 L-malate
-
 Erwinia aroidea
0.7
-
 L-malate
-
 Escherichia coli W
0.8
-
 L-malate
-
 Citrobacter freundii
1
-
 L-malate
-
 Escherichia coli K-12
1.2
-
 L-malate
-
 Escherichia coli B
2.2
-
 L-malate
-
 Agrobacterium tumefaciens
4.3
-
 L-malate
-
 Klebsiella aerogenes

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
84000
-
 gel filtration Clostridium tetanomorphum
140000
-
 gel filtration Klebsiella aerogenes
180000
-
 gel filtration Proteus vulgaris
190000
-
 gel filtration Citrobacter freundii
200000
-
 gel filtration Erwinia aroidea
200000
-
 gel filtration Escherichia coli B
220000
-
-
 Escherichia coli W
220000
-
 gel filtration Escherichia coli K-12
220000
-
 gel filtration Escherichia coli B
240000
-
 gel filtration Klebsiella aerogenes
580000
-
 gel filtration Agrobacterium tumefaciens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(S)-malate + NAD+ Klebsiella aerogenes
-
 CO2 + pyruvate + NADH
-
 ?
(S)-malate + NAD+ Proteus vulgaris
-
 CO2 + pyruvate + NADH
-
 ?
(S)-malate + NAD+ Citrobacter freundii
-
 CO2 + pyruvate + NADH
-
 ?
(S)-malate + NAD+ Clostridium tetanomorphum
-
 CO2 + pyruvate + NADH
-
 ?
(S)-malate + NAD+ Agrobacterium tumefaciens
-
 CO2 + pyruvate + NADH
-
 ?
(S)-malate + NAD+ Erwinia aroidea
-
 CO2 + pyruvate + NADH
-
 ?
(S)-malate + NAD+ Escherichia coli K-12
-
 CO2 + pyruvate + NADH
-
 ?
(S)-malate + NAD+ Escherichia coli W
-
 CO2 + pyruvate + NADH
-
 ?
(S)-malate + NAD+ Escherichia coli B
-
 CO2 + pyruvate + NADH
-
 ?
(S)-malate + NAD+ Klebsiella aerogenes IFO 3320
-
 CO2 + pyruvate + NADH
-
 ?
Oxaloacetate Klebsiella aerogenes
-
 CO2 + pyruvate
-
 ir
Oxaloacetate Proteus vulgaris
-
 CO2 + pyruvate
-
 ir
Oxaloacetate Citrobacter freundii
-
 CO2 + pyruvate
-
 ir
Oxaloacetate Clostridium tetanomorphum
-
 CO2 + pyruvate
-
 ir
Oxaloacetate Agrobacterium tumefaciens
-
 CO2 + pyruvate
-
 ir
Oxaloacetate Erwinia aroidea
-
 CO2 + pyruvate
-
 ir
Oxaloacetate Escherichia coli K-12
-
 CO2 + pyruvate
-
 ir
Oxaloacetate Escherichia coli W
-
 CO2 + pyruvate
-
 ir
Oxaloacetate Escherichia coli B
-
 CO2 + pyruvate
-
 ir
Oxaloacetate Klebsiella aerogenes IFO 3320
-
 CO2 + pyruvate
-
 ir

Organism

Organism UniProt Comment Textmining
Agrobacterium tumefaciens
-
-
-
Citrobacter freundii
-
-
-
Clostridium tetanomorphum
-
-
-
Erwinia aroidea
-
-
-
Escherichia coli B
-
-
-
Escherichia coli K-12
-
-
-
Escherichia coli W
-
-
-
Klebsiella aerogenes
-
-
-
Klebsiella aerogenes IFO 3320
-
-
-
Proteus vulgaris
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.3
-
-
 Escherichia coli B
5.5
-
-
 Klebsiella aerogenes
7
-
-
 Clostridium tetanomorphum
8.1
-
-
 Escherichia coli W
9
-
-
 Escherichia coli K-12
30
-
-
 Erwinia aroidea
32
-
-
 Klebsiella aerogenes
65
-
-
 Agrobacterium tumefaciens
70
-
-
 Proteus vulgaris
93
-
-
 Citrobacter freundii

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(S)-malate + NAD+
-
 Klebsiella aerogenes CO2 + pyruvate + NADH
-
 ?
(S)-malate + NAD+
-
 Klebsiella aerogenes CO2 + pyruvate + NADH
-
 r
(S)-malate + NAD+
-
 Proteus vulgaris CO2 + pyruvate + NADH
-
 ?
(S)-malate + NAD+
-
 Proteus vulgaris CO2 + pyruvate + NADH
-
 r
(S)-malate + NAD+
-
 Citrobacter freundii CO2 + pyruvate + NADH
-
 ?
(S)-malate + NAD+
-
 Citrobacter freundii CO2 + pyruvate + NADH
-
 r
(S)-malate + NAD+
-
 Clostridium tetanomorphum CO2 + pyruvate + NADH
-
 ?
(S)-malate + NAD+
-
 Clostridium tetanomorphum CO2 + pyruvate + NADH
-
 r
(S)-malate + NAD+
-
 Agrobacterium tumefaciens CO2 + pyruvate + NADH
-
 ?
(S)-malate + NAD+
-
 Agrobacterium tumefaciens CO2 + pyruvate + NADH
-
 r
(S)-malate + NAD+
-
 Erwinia aroidea CO2 + pyruvate + NADH
-
 ?
(S)-malate + NAD+
-
 Erwinia aroidea CO2 + pyruvate + NADH
-
 r
(S)-malate + NAD+
-
 Escherichia coli K-12 CO2 + pyruvate + NADH
-
 ?
(S)-malate + NAD+
-
 Escherichia coli K-12 CO2 + pyruvate + NADH
-
 r
(S)-malate + NAD+
-
 Escherichia coli W CO2 + pyruvate + NADH
-
 ?
(S)-malate + NAD+
-
 Escherichia coli W CO2 + pyruvate + NADH
-
 r
(S)-malate + NAD+
-
 Escherichia coli B CO2 + pyruvate + NADH
-
 ?
(S)-malate + NAD+
-
 Escherichia coli B CO2 + pyruvate + NADH
-
 r
(S)-malate + NAD+
-
 Klebsiella aerogenes IFO 3320 CO2 + pyruvate + NADH
-
 ?
(S)-malate + NAD+
-
 Klebsiella aerogenes IFO 3320 CO2 + pyruvate + NADH
-
 r
Oxaloacetate
-
 Klebsiella aerogenes CO2 + pyruvate
-
 ir
Oxaloacetate
-
 Proteus vulgaris CO2 + pyruvate
-
 ir
Oxaloacetate
-
 Citrobacter freundii CO2 + pyruvate
-
 ir
Oxaloacetate
-
 Clostridium tetanomorphum CO2 + pyruvate
-
 ir
Oxaloacetate
-
 Agrobacterium tumefaciens CO2 + pyruvate
-
 ir
Oxaloacetate
-
 Erwinia aroidea CO2 + pyruvate
-
 ir
Oxaloacetate
-
 Escherichia coli K-12 CO2 + pyruvate
-
 ir
Oxaloacetate
-
 Escherichia coli W CO2 + pyruvate
-
 ir
Oxaloacetate
-
 Escherichia coli B CO2 + pyruvate
-
 ir
Oxaloacetate
-
 Klebsiella aerogenes IFO 3320 CO2 + pyruvate
-
 ir

Cofactor

Cofactor Comment Organism Structure
NAD+
-
 Klebsiella aerogenes
NAD+
-
 Proteus vulgaris
NAD+
-
 Citrobacter freundii
NAD+
-
 Clostridium tetanomorphum
NAD+
-
 Agrobacterium tumefaciens
NAD+
-
 Erwinia aroidea
NAD+
-
 Escherichia coli K-12
NAD+
-
 Escherichia coli W
NAD+
-
 Escherichia coli B