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Literature summary for 1.1.1.375 extracted from

  • Graupner, M.; Xu, H.; White, R.H.
    Identification of an archaeal 2-hydroxy acid dehydrogenase catalyzing reactions involved in coenzyme biosynthesis in methanoarchaea (2000), J. Bacteriol., 182, 3688-3692.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
overexpressed in Escherichia coli Methanocaldococcus jannaschii

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.025
-
(S)-malate 70°C, pH 9.5, cofactor: NADP+ Methanocaldococcus jannaschii
0.15
-
(S)-malate 70°C, pH 9.5, cofactor: NAD+ Methanocaldococcus jannaschii
0.19
-
3-sulfopyruvate 70°C, pH 8.0, cofactor: NADPH Methanocaldococcus jannaschii
0.25
-
oxaloacetate 70°C, pH 8.0, cofactor: NADH Methanocaldococcus jannaschii
0.3
-
oxaloacetate 70°C, pH 8.0, cofactor: NADPH Methanocaldococcus jannaschii
1.3
-
3-sulfopyruvate 70°C, pH 8.0, cofactor: NADH Methanocaldococcus jannaschii
4.6
-
(2S)-3-sulfolactate 70°C, pH 9.5, cofactor: NADP+ Methanocaldococcus jannaschii

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3-sulfopyruvate + NADPH + H+ Methanocaldococcus jannaschii
-
(2S)-3-sulfolactate + NADP+
-
r

Organism

Organism UniProt Comment Textmining
Methanocaldococcus jannaschii Q60176
-
-
Methanocaldococcus jannaschii DSM 2661 Q60176
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(2S)-3-sulfolactate + NADP+ weak activity, Vmax/KM: 1/min*mg. The enzyme does not catalyse the oxidation of (2S)-3-sulfolactate with NAD+ as cofactor Methanocaldococcus jannaschii 3-sulfopyruvate + NADPH + H+
-
r
(S)-malate + NAD+ Vmax/KM: 4/min*mg. The enzyme prefers NADP+ over NAD+ in oxidation of (S)-malate Methanocaldococcus jannaschii oxaloacetate + NADH + H+
-
r
(S)-malate + NAD+ Vmax/KM: 4/min*mg. The enzyme prefers NADP+ over NAD+ in oxidation of (S)-malate Methanocaldococcus jannaschii DSM 2661 oxaloacetate + NADH + H+
-
r
(S)-malate + NADP+ Vmax/KM: 110/min*mg. The enzyme prefers NADP+ over NAD+ in oxidation of (S)-malate Methanocaldococcus jannaschii oxaloacetate + NADPH + H+
-
r
(S)-malate + NADP+ Vmax/KM: 110/min*mg. The enzyme prefers NADP+ over NAD+ in oxidation of (S)-malate Methanocaldococcus jannaschii DSM 2661 oxaloacetate + NADPH + H+
-
r
3-sulfopyruvate + NADH + H+ Vmax/KM: 34/min*mg. The enzyme prefers oxaloacetate over 3-sulfopyruvate using NADH as cofactor Methanocaldococcus jannaschii (2S)-3-sulfolactate + NAD+
-
ir
3-sulfopyruvate + NADPH + H+
-
Methanocaldococcus jannaschii (2S)-3-sulfolactate + NADP+
-
r
3-sulfopyruvate + NADPH + H+ Vmax/KM: 590/min*mg. The enzyme prefers NADPH over NADH in reduction of 3-sulfopyruvate Methanocaldococcus jannaschii (2S)-3-sulfolactate + NADP+
-
r
additional information no activity with 2-oxoglutarate and 1-oxo-1,3,4,6-hexanetetracarboxylic acid Methanocaldococcus jannaschii ?
-
?
additional information no activity with 2-oxoglutarate and 1-oxo-1,3,4,6-hexanetetracarboxylic acid Methanocaldococcus jannaschii DSM 2661 ?
-
?
oxaloacetate + NADH + H+ Vmax/KM: 120 /min*mg. The enzyme prefers oxaloacetate over 3-sulfopyruvate using NADH as cofactor. The enzyme prefers NADPH over NADH in reduction of oxaloacetate Methanocaldococcus jannaschii (S)-malate + NAD+
-
r
oxaloacetate + NADH + H+ Vmax/KM: 120 /min*mg. The enzyme prefers oxaloacetate over 3-sulfopyruvate using NADH as cofactor. The enzyme prefers NADPH over NADH in reduction of oxaloacetate Methanocaldococcus jannaschii DSM 2661 (S)-malate + NAD+
-
r
oxaloacetate + NADPH + H+ Vmax/KM: 160/min*mg. The enzyme prefers NADPH over NADH in reduction of oxaloacetate Methanocaldococcus jannaschii (S)-malate + NADP+
-
r
oxaloacetate + NADPH + H+ Vmax/KM: 160/min*mg. The enzyme prefers NADPH over NADH in reduction of oxaloacetate Methanocaldococcus jannaschii DSM 2661 (S)-malate + NADP+
-
r

Synonyms

Synonyms Comment Organism
MdhII
-
Methanocaldococcus jannaschii
MJ0490 locus name Methanocaldococcus jannaschii

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
70
-
assay at Methanocaldococcus jannaschii

Cofactor

Cofactor Comment Organism Structure
NAD+ the enzyme prefers NADP+ over NAD+ in oxidation of (S)-malate Methanocaldococcus jannaschii
NADH the enzyme prefers NADPH over NADH in reduction of oxaloacetate Methanocaldococcus jannaschii
NADP+ the enzyme prefers NADP+ over NAD+ in oxidation of (S)-malate Methanocaldococcus jannaschii
NADPH the enzyme prefers NADPH over NADH in reduction of oxaloacetate or 3-sulfopyruvate Methanocaldococcus jannaschii