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Literature summary for 1.1.1.37 extracted from

  • Storer, A.C.; Sprott, G.D.; Martin, W.G.
    Kinetic and physical properties of the L-malate-NAD+ oxidoreductase from Methanospirillum hungatii and comparison with the enzyme from other sources (1981), Biochem. J., 193, 235-244.
    View publication on PubMedView publication on EuropePMC

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.027
-
oxaloacetate
-
Methanospirillum hungatei
0.08
-
NADH
-
Methanospirillum hungatei

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
Sus scrofa 5737
-
cytoplasm
-
Saccharomyces cerevisiae 5737
-
cytoplasm
-
Bos taurus 5737
-
cytoplasm
-
Neurospora crassa 5737
-
cytoplasm
-
Gallus sp. 5737
-
cytoplasm
-
Equus sp. 5737
-
cytoplasm
-
Thunnus albacares 5737
-
mitochondrion
-
Thermus thermophilus 5739
-
mitochondrion
-
Rattus norvegicus 5739
-
mitochondrion
-
Sus scrofa 5739
-
mitochondrion
-
Saccharomyces cerevisiae 5739
-
mitochondrion
-
Bos taurus 5739
-
mitochondrion
-
Neurospora crassa 5739
-
mitochondrion
-
Gallus sp. 5739
-
mitochondrion
-
Equus sp. 5739
-
mitochondrion
-
Thunnus albacares 5739
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
31350
-
2 * 31350, SDS-PAGE Methanospirillum hungatei
52000
-
s-MDH Bos taurus
53000
-
-
Mycobacterium sp.
54000
-
-
Neurospora crassa
60000
-
-
Thermus thermophilus
60000
-
-
Escherichia coli
60000
-
-
Sus scrofa
61700
-
gel filtration Methanospirillum hungatei
62000
-
m-MDH Bos taurus
64200
-
ultracentrifugation equlibrium Methanospirillum hungatei
67000
-
-
Thermus thermophilus
67000
-
-
Sus scrofa
67000
-
-
Neurospora crassa
67000
-
-
Gallus sp.
67000
-
-
Thunnus albacares
68000
-
-
Sus scrofa
68000
-
-
Salmo sp.
68000
-
m-MDH Saccharomyces cerevisiae
70000
-
-
Rattus norvegicus
70000
-
-
Comamonas testosteroni
70000
-
-
Thunnus albacares
72000
-
-
Thermus thermophilus
72000
-
-
Sus scrofa
73500
-
-
Thermus aquaticus
75000
-
-
Comamonas testosteroni
75000
-
s-MDH Saccharomyces cerevisiae
84000
-
-
Halobacterium salinarum
86860
-
-
Mycolicibacterium phlei
148000
-
-
Bacillus subtilis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
malate + NAD+ Thermus aquaticus
-
oxaloacetate + NADH + H+
-
r
malate + NAD+ Bacillus subtilis
-
oxaloacetate + NADH + H+
-
r
malate + NAD+ Thermus thermophilus
-
oxaloacetate + NADH + H+
-
r
malate + NAD+ Escherichia coli
-
oxaloacetate + NADH + H+
-
r
malate + NAD+ Rattus norvegicus
-
oxaloacetate + NADH + H+
-
r
malate + NAD+ Sus scrofa
-
oxaloacetate + NADH + H+
-
r
malate + NAD+ Saccharomyces cerevisiae
-
oxaloacetate + NADH + H+
-
r
malate + NAD+ Bos taurus
-
oxaloacetate + NADH + H+
-
r
malate + NAD+ Neurospora crassa
-
oxaloacetate + NADH + H+
-
r
malate + NAD+ Halobacterium salinarum
-
oxaloacetate + NADH + H+
-
r
malate + NAD+ Mycolicibacterium phlei
-
oxaloacetate + NADH + H+
-
r
malate + NAD+ Mycobacterium sp.
-
oxaloacetate + NADH + H+
-
r
malate + NAD+ Comamonas testosteroni
-
oxaloacetate + NADH + H+
-
r
malate + NAD+ Gallus sp.
-
oxaloacetate + NADH + H+
-
r
malate + NAD+ Equus sp.
-
oxaloacetate + NADH + H+
-
r
malate + NAD+ Thunnus albacares
-
oxaloacetate + NADH + H+
-
r
malate + NAD+ Salmo sp.
-
oxaloacetate + NADH + H+
-
r

Organism

Organism UniProt Comment Textmining
Bacillus subtilis
-
-
-
Bos taurus
-
-
-
Comamonas testosteroni
-
-
-
Equus sp.
-
-
-
Escherichia coli
-
-
-
Gallus sp.
-
chicken
-
Halobacterium salinarum
-
-
-
Methanospirillum hungatei
-
-
-
Methanospirillum hungatei GPI
-
-
-
Mycobacterium sp.
-
-
-
Mycolicibacterium phlei
-
-
-
Neurospora crassa
-
-
-
Rattus norvegicus
-
rat
-
Saccharomyces cerevisiae
-
yeast
-
Salmo sp.
-
salmon
-
Sus scrofa
-
pig
-
Thermus aquaticus
-
-
-
Thermus thermophilus
-
-
-
Thunnus albacares
-
tuna
-

Purification (Commentary)

Purification (Comment) Organism
-
Methanospirillum hungatei

Source Tissue

Source Tissue Comment Organism Textmining
heart
-
Sus scrofa
-
heart
-
Bos taurus
-
heart
-
Gallus sp.
-
heart
-
Equus sp.
-
heart
-
Thunnus albacares
-
heart
-
Salmo sp.
-
liver
-
Rattus norvegicus
-
liver
-
Gallus sp.
-
muscle
-
Salmo sp.
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
62
-
-
Methanospirillum hungatei

Storage Stability

Storage Stability Organism
4°C, at pH 8 in 0.05 M Tris/HCl containing 1 M NaCl, several weeks without appreciable loss of activity Methanospirillum hungatei

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(S)-malate + NAD+
-
Thermus aquaticus oxaloacetate + NADH + H+
-
r
(S)-malate + NAD+
-
Bacillus subtilis oxaloacetate + NADH + H+
-
r
(S)-malate + NAD+
-
Thermus thermophilus oxaloacetate + NADH + H+
-
r
(S)-malate + NAD+
-
Escherichia coli oxaloacetate + NADH + H+
-
r
(S)-malate + NAD+
-
Rattus norvegicus oxaloacetate + NADH + H+
-
r
(S)-malate + NAD+
-
Sus scrofa oxaloacetate + NADH + H+
-
r
(S)-malate + NAD+
-
Saccharomyces cerevisiae oxaloacetate + NADH + H+
-
r
(S)-malate + NAD+
-
Bos taurus oxaloacetate + NADH + H+
-
r
(S)-malate + NAD+
-
Neurospora crassa oxaloacetate + NADH + H+
-
r
(S)-malate + NAD+
-
Halobacterium salinarum oxaloacetate + NADH + H+
-
r
(S)-malate + NAD+
-
Mycolicibacterium phlei oxaloacetate + NADH + H+
-
r
(S)-malate + NAD+
-
Mycobacterium sp. oxaloacetate + NADH + H+
-
r
(S)-malate + NAD+
-
Comamonas testosteroni oxaloacetate + NADH + H+
-
r
(S)-malate + NAD+
-
Gallus sp. oxaloacetate + NADH + H+
-
r
(S)-malate + NAD+
-
Equus sp. oxaloacetate + NADH + H+
-
r
(S)-malate + NAD+
-
Thunnus albacares oxaloacetate + NADH + H+
-
r
(S)-malate + NAD+
-
Salmo sp. oxaloacetate + NADH + H+
-
r
malate + NAD+
-
Thermus aquaticus oxaloacetate + NADH + H+
-
r
malate + NAD+
-
Bacillus subtilis oxaloacetate + NADH + H+
-
r
malate + NAD+
-
Thermus thermophilus oxaloacetate + NADH + H+
-
r
malate + NAD+
-
Escherichia coli oxaloacetate + NADH + H+
-
r
malate + NAD+
-
Rattus norvegicus oxaloacetate + NADH + H+
-
r
malate + NAD+
-
Sus scrofa oxaloacetate + NADH + H+
-
r
malate + NAD+
-
Saccharomyces cerevisiae oxaloacetate + NADH + H+
-
r
malate + NAD+
-
Bos taurus oxaloacetate + NADH + H+
-
r
malate + NAD+
-
Neurospora crassa oxaloacetate + NADH + H+
-
r
malate + NAD+
-
Halobacterium salinarum oxaloacetate + NADH + H+
-
r
malate + NAD+
-
Mycolicibacterium phlei oxaloacetate + NADH + H+
-
r
malate + NAD+
-
Mycobacterium sp. oxaloacetate + NADH + H+
-
r
malate + NAD+
-
Comamonas testosteroni oxaloacetate + NADH + H+
-
r
malate + NAD+
-
Gallus sp. oxaloacetate + NADH + H+
-
r
malate + NAD+
-
Equus sp. oxaloacetate + NADH + H+
-
r
malate + NAD+
-
Thunnus albacares oxaloacetate + NADH + H+
-
r
malate + NAD+
-
Salmo sp. oxaloacetate + NADH + H+
-
r
oxaloacetate + NADH
-
Thermus aquaticus L-malate + NAD+
-
r
oxaloacetate + NADH
-
Bacillus subtilis L-malate + NAD+
-
r
oxaloacetate + NADH
-
Thermus thermophilus L-malate + NAD+
-
r
oxaloacetate + NADH
-
Escherichia coli L-malate + NAD+
-
r
oxaloacetate + NADH
-
Rattus norvegicus L-malate + NAD+
-
r
oxaloacetate + NADH
-
Sus scrofa L-malate + NAD+
-
r
oxaloacetate + NADH
-
Saccharomyces cerevisiae L-malate + NAD+
-
r
oxaloacetate + NADH
-
Bos taurus L-malate + NAD+
-
r
oxaloacetate + NADH
-
Neurospora crassa L-malate + NAD+
-
r
oxaloacetate + NADH
-
Halobacterium salinarum L-malate + NAD+
-
r
oxaloacetate + NADH
-
Mycolicibacterium phlei L-malate + NAD+
-
r
oxaloacetate + NADH
-
Mycobacterium sp. L-malate + NAD+
-
r
oxaloacetate + NADH
-
Comamonas testosteroni L-malate + NAD+
-
r
oxaloacetate + NADH
-
Methanospirillum hungatei L-malate + NAD+
-
ir
oxaloacetate + NADH
-
Gallus sp. L-malate + NAD+
-
r
oxaloacetate + NADH
-
Equus sp. L-malate + NAD+
-
r
oxaloacetate + NADH
-
Thunnus albacares L-malate + NAD+
-
r
oxaloacetate + NADH
-
Salmo sp. L-malate + NAD+
-
r
oxaloacetate + NADH
-
Methanospirillum hungatei GPI L-malate + NAD+
-
ir

Subunits

Subunits Comment Organism
dimer
-
Thermus aquaticus
dimer
-
Thermus thermophilus
dimer
-
Sus scrofa
dimer
-
Saccharomyces cerevisiae
dimer
-
Bos taurus
dimer
-
Halobacterium salinarum
dimer
-
Comamonas testosteroni
dimer 2 * 31350, SDS-PAGE Methanospirillum hungatei

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
70
-
-
Thermus aquaticus