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Literature summary for 1.1.1.363 extracted from

  • Kurlandsky, S.B.; Hilburger, A.C.; Levy, H.R.
    Glucose-6-phosphate dehydrogenase from Leuconostoc mesenteroides: ligand-induced conformational changes (1988), Arch. Biochem. Biophys., 264, 93-102.
    View publication on PubMed

General Stability

General Stability Organism
chymotrypsin inactivates. First order rate constant for inactivation is 0.02/min. Protection by 72 mM NAD+ or by 6.3 mM glucose 6-phosphate or 72 mM NADP+ Leuconostoc mesenteroides
pronase inactivates. First order rate constant for inactivation is 0.012/min. Protection by 72 mM NAD+ or by 6.3 mM glucose 6-phosphate or 72 mM NADP+ Leuconostoc mesenteroides
thermolysin inactivates. First order rate constant for inactivation is 0.057/min. Protection by 72 mM NAD+ or by 6.3 mM glucose 6-phosphate or 72 mM NADP+ Leuconostoc mesenteroides
trypsin inactivates. First order rate constant for inactivation is 0.025/min. Protection by 72 mM NAD+ or by 6.3 mM glucose 6-phosphate or 72 mM NADP+ Leuconostoc mesenteroides

Inhibitors

Inhibitors Comment Organism Structure
NADP+
-
Leuconostoc mesenteroides

Organic Solvent Stability

Organic Solvent Comment Organism
urea 4 M. First order rate constant for inactivation is 0.019/min. Protection by 72 mM NAD+ or by 6.3 mM glucose 6-phosphate or 72 mM NADP+ Leuconostoc mesenteroides

Organism

Organism UniProt Comment Textmining
Leuconostoc mesenteroides
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-glucose 6-phosphate + NAD+
-
Leuconostoc mesenteroides 6-phospho-D-glucono-1,5-lactone + NADH + H+
-
?
D-glucose 6-phosphate + NADP+
-
Leuconostoc mesenteroides 6-phospho-D-glucono-1,5-lactone + NADPH + H+
-
?

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
49
-
first order rate constant for inactivation is 0.05/min. Protection by 72 mM NAD+ or by 6.3 mM glucose 6-phosphate or 72 mM NADP+ Leuconostoc mesenteroides

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Leuconostoc mesenteroides
NADP+
-
Leuconostoc mesenteroides