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Literature summary for 1.1.1.363 extracted from

  • Grove, T.H.; Ishaque, A.; Levy, H.R.
    Glucose-6-phosphate dehydrogenase from Leuconostoc mesenteroides. Interaction of the enzyme with coenzymes and coenzyme analogs (1976), Arch. Biochem. Biophys., 17, 307-316.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
2',5'-ADP NADP+-competitive and NAD+-noncompetitive inhibition Leuconostoc mesenteroides
2'-AMP
-
Leuconostoc mesenteroides
5'-AMP
-
Leuconostoc mesenteroides
adenosine
-
Leuconostoc mesenteroides
ADP
-
Leuconostoc mesenteroides
ADP-ribose
-
Leuconostoc mesenteroides
ATP
-
Leuconostoc mesenteroides
D-glucose 1-phosphate a substrate-competitive inhibitor, that lowers the dissociation constant and maximum fluorescence quenching for NAD+ but not for NADP+ Leuconostoc mesenteroides
N'-methylnicotinamide
-
Leuconostoc mesenteroides
nicotinamide
-
Leuconostoc mesenteroides

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
D-glucose 6-phosphate + NAD+ Leuconostoc mesenteroides
-
6-phospho-D-glucono-1,5-lactone + NADH + H+
-
?
D-glucose 6-phosphate + NADP+ Leuconostoc mesenteroides
-
6-phospho-D-glucono-1,5-lactone + NADPH + H+
-
?

Organism

Organism UniProt Comment Textmining
Leuconostoc mesenteroides
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Leuconostoc mesenteroides

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-glucose 6-phosphate + NAD+
-
Leuconostoc mesenteroides 6-phospho-D-glucono-1,5-lactone + NADH + H+
-
?
D-glucose 6-phosphate + NADP+
-
Leuconostoc mesenteroides 6-phospho-D-glucono-1,5-lactone + NADPH + H+
-
?

Cofactor

Cofactor Comment Organism Structure
NAD+ the maximum quenching of protein fluorescence is 50% for NAD+. The dissociation constant for NAD+ is 2.5 mM Leuconostoc mesenteroides
NADP+ the maximum quenching of protein fluorescence is 5% for NADP+. The dissociation constant for NADP+ is 0.003 mM Leuconostoc mesenteroides

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.12
-
2',5'-ADP pH 7.8, 25°C, substrate: NADP+ Leuconostoc mesenteroides
0.52
-
ADP-ribose pH 7.8, 25°C, substrate: NAD+ Leuconostoc mesenteroides
1.3
-
2'-AMP pH 7.8, 25°C, substrate: NAD+ Leuconostoc mesenteroides
1.5
-
ATP pH 7.8, 25°C, substrate: NADP+ Leuconostoc mesenteroides
2
-
5'-AMP pH 7.8, 25°C, substrate: NAD+ Leuconostoc mesenteroides
3.1
-
ADP pH 7.8, 25°C, substrate: NAD+ Leuconostoc mesenteroides
36
-
adenosine pH 7.8, 25°C, substrate: NAD+ Leuconostoc mesenteroides
95
-
N'-methylnicotinamide pH 7.8, 25°C, substrate: NAD+ Leuconostoc mesenteroides
105
-
nicotinamide pH 7.8, 25°C, substrate: NAD+ Leuconostoc mesenteroides