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Literature summary for 1.1.1.362 extracted from

  • Dickens, M.L.; Ye, J.; Strohl, W.R.
    Cloning, sequencing, and analysis of aklaviketone reductase from Streptomyces sp. strain C5 (1996), J. Bacteriol., 178, 3384-3388.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
extracts of Streptomyces lividans TK24 containing recombinant DauE catalyzes the NADPH-specific conversion of aklaviketone, maggiemycin, and 7-oxodaunomycinone to aklavinone, epsilon-rhodomycinone, and daunomycinone, respectively Streptomyces sp.

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
25632
-
x * 25632, calculated from sequence Streptomyces sp.

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
aklaviketone + NADPH + H+ Streptomyces sp. the enzyme is involved in the biosynthesis of the anthracyclins aclacinomycin and daunomycin. Aklavinone is the last intermediate common to both aclacinomycin and daunomycin biosynthesis aklavinone + NADP+
-
?

Organism

Organism UniProt Comment Textmining
Streptomyces sp. Q53882
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7-oxodaunomycinone + NADPH + H+
-
Streptomyces sp. daunomycinone + NADP+
-
?
aklaviketone + NADPH + H+ the enzyme is involved in the biosynthesis of the anthracyclins aclacinomycin and daunomycin. Aklavinone is the last intermediate common to both aclacinomycin and daunomycin biosynthesis Streptomyces sp. aklavinone + NADP+
-
?
aklaviketone + NADPH + H+ activity with NADH is 7% of the activity with NADPH Streptomyces sp. aklavinone + NADP+
-
?
maggiemycin + NADPH + H+
-
Streptomyces sp. epsilon-rhodomycinone + NADP+
-
?

Subunits

Subunits Comment Organism
? x * 25632, calculated from sequence Streptomyces sp.

Synonyms

Synonyms Comment Organism
DauE
-
Streptomyces sp.

Cofactor

Cofactor Comment Organism Structure
NADPH activity with NADH is 7% of the activity with NADPH Streptomyces sp.

General Information

General Information Comment Organism
physiological function the enzyme is involved in the biosynthesis of the anthracyclins aclacinomycin and daunomycin Streptomyces sp.