Cloned (Comment) | Organism |
---|---|
extracts of Streptomyces lividans TK24 containing recombinant DauE catalyzes the NADPH-specific conversion of aklaviketone, maggiemycin, and 7-oxodaunomycinone to aklavinone, epsilon-rhodomycinone, and daunomycinone, respectively | Streptomyces sp. |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
25632 | - |
x * 25632, calculated from sequence | Streptomyces sp. |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
aklaviketone + NADPH + H+ | Streptomyces sp. | the enzyme is involved in the biosynthesis of the anthracyclins aclacinomycin and daunomycin. Aklavinone is the last intermediate common to both aclacinomycin and daunomycin biosynthesis | aklavinone + NADP+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Streptomyces sp. | Q53882 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
7-oxodaunomycinone + NADPH + H+ | - |
Streptomyces sp. | daunomycinone + NADP+ | - |
? | |
aklaviketone + NADPH + H+ | the enzyme is involved in the biosynthesis of the anthracyclins aclacinomycin and daunomycin. Aklavinone is the last intermediate common to both aclacinomycin and daunomycin biosynthesis | Streptomyces sp. | aklavinone + NADP+ | - |
? | |
aklaviketone + NADPH + H+ | activity with NADH is 7% of the activity with NADPH | Streptomyces sp. | aklavinone + NADP+ | - |
? | |
maggiemycin + NADPH + H+ | - |
Streptomyces sp. | epsilon-rhodomycinone + NADP+ | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 25632, calculated from sequence | Streptomyces sp. |
Synonyms | Comment | Organism |
---|---|---|
DauE | - |
Streptomyces sp. |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | activity with NADH is 7% of the activity with NADPH | Streptomyces sp. |
General Information | Comment | Organism |
---|---|---|
physiological function | the enzyme is involved in the biosynthesis of the anthracyclins aclacinomycin and daunomycin | Streptomyces sp. |