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Literature summary for 1.1.1.36 extracted from

  • Han, J.; Lu, Q.; Zhou, L.; Liu, H.; Xiang, H.
    Identification of the polyhydroxyalkanoate (PHA)-specific acetoacetyl coenzyme A reductase among multiple FabG paralogs in Haloarcula hispanica and reconstruction of the PHA biosynthetic pathway in Haloferax volcanii (2009), Appl. Environ. Microbiol., 75, 6168-6175.
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
gene fabG1, DNA sequence determination and analysis, expression in the fabG1-deficient mutant, phylogenetic tree, sequence comparison of FabG1 to FabG6 Haloarcula hispanica

Protein Variants

Protein Variants Comment Organism
additional information disruption or knockout of fabG1 abolishes HA synthesis, and complementation of the DELTAfabG1 mutant with the fabG1 gene restores both PHA synthesis capability and the NADPH-dependent acetoacetyl-CoA reductase activity. Heterologous coexpression of the PHA synthase genes, phaEC together with fabG1, but not its five paralogs, reconstructs the PHA biosynthetic pathway in Haloferax volcanii, a PHA-defective haloarchaeon Haloarcula hispanica

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acetoacetyl-CoA + NADPH + H+ Haloarcula hispanica FabG1 exhibits NADPH-dependent activity of acetoacetyl-CoA reductase (R)-3-hydroxybutyryl-CoA + NADP+
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 ?
acetoacetyl-CoA + NADPH + H+ Haloarcula hispanica DSM 4426 FabG1 exhibits NADPH-dependent activity of acetoacetyl-CoA reductase (R)-3-hydroxybutyryl-CoA + NADP+
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 ?

Organism

Organism UniProt Comment Textmining
Haloarcula hispanica G0HY85 or ATCC 33960, gene fabG1
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Haloarcula hispanica DSM 4426 G0HY85 or ATCC 33960, gene fabG1
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetoacetyl-CoA + NADPH + H+
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 Haloarcula hispanica (R)-3-hydroxybutyryl-CoA + NADP+
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 ?
acetoacetyl-CoA + NADPH + H+ FabG1 exhibits NADPH-dependent activity of acetoacetyl-CoA reductase Haloarcula hispanica (R)-3-hydroxybutyryl-CoA + NADP+
-
 ?
acetoacetyl-CoA + NADPH + H+
-
 Haloarcula hispanica DSM 4426 (R)-3-hydroxybutyryl-CoA + NADP+
-
 ?
acetoacetyl-CoA + NADPH + H+ FabG1 exhibits NADPH-dependent activity of acetoacetyl-CoA reductase Haloarcula hispanica DSM 4426 (R)-3-hydroxybutyryl-CoA + NADP+
-
 ?

Synonyms

Synonyms Comment Organism
More FabG belongs to the short-chain dehydrogenase/reductase superfamily, whose members are homologous in sequence and have several conserved motifs Haloarcula hispanica
PHA-specific acetoacetyl-CoA reductase
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 Haloarcula hispanica
polyhydroxyalkanoate-specific acetoacetyl coenzyme A reductase
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 Haloarcula hispanica

Cofactor

Cofactor Comment Organism Structure
NADPH
-
 Haloarcula hispanica