Crystallization (Comment) | Organism |
---|---|
crystal structure of the human 3alpha-HSD type 3 in the ternary complex with testosterone and NADP+ determined by molecular replacement method using the program EPMR, at 1.25-A resolution, binding site analysis | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | Km-value for the 17beta-oxidation of testosterone is 0.00067 mM, and Km-value for the 17beta-reduction of androstenedione is 0.00138 mM | Homo sapiens | |
0.0011 | - |
dihydrotestosterone | pH 7.5, 37°C | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P52895 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
dihydrotestosterone + NAD(P)H + H+ | - |
Homo sapiens | 5alpha-androstane-3alpha,17beta-diol + NAD(P)+ | - |
? | |
additional information | the enzyme also exhibits a weak 17beta-hydroxysteroid dehydrogenase activity transforming androstenedione into testosterone | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
3alpha-HSD3 | - |
Homo sapiens |
AKR1C2 | - |
Homo sapiens |
type 3 3alpha-hydroxysteroid dehydrogenase | - |
Homo sapiens |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | Kcat-value for the 17beta-oxidation of testosterone is 0.000118 1/sec, and Kcat-value for the 17beta-reduction of androstenedione is 0.00112 1/sec | Homo sapiens | |
0.025 | - |
dihydrotestosterone | pH 7.5, 37°C | Homo sapiens |
General Information | Comment | Organism |
---|---|---|
metabolism | enzyme is involved in the inactivation of steroid hormones | Homo sapiens |
kcat/KM Value [1/mMs-1] | kcat/KM Value Maximum [1/mMs-1] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | Kcat/Km-value for the 17beta-oxidation of testosterone is 0.183 1/sec*mM, and Kcat/Km-value for the 17beta-reduction of androstenedione is 0.817 1/sec*mM | Homo sapiens | |
22.7 | - |
dihydrotestosterone | pH 7.5, 37°C | Homo sapiens |