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Literature summary for 1.1.1.357 extracted from

  • Shiraishi, H.; Ishikura, S.; Matsuura, K.; Deyashiki, Y.; Ninomiya, M.; Sakai, S.; Hara, A.
    Sequence of the cDNA of a human dihydrodiol dehydrogenase isoform (AKR1C2) and tissue distribution of its mRNA (1998), Biochem. J., 334, 399-405.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.1.1.357

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
chenodeoxycholic acid
-
 Homo sapiens
Flufenamic acid
-
 Homo sapiens
Hexestrol
-
 Homo sapiens
Ibuprofen
-
 Homo sapiens
indomethacin
-
 Homo sapiens
lithocholic acid
-
 Homo sapiens
Medroxyprogesterone acetate
-
 Homo sapiens
Phenolphthalein
-
 Homo sapiens
Ursodeoxycholic acid
-
 Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.001
-
 5beta-pregnane-3alpha,20alpha-diol native enzyme, at pH 7.4 and 25°C Homo sapiens
0.001
-
 5beta-pregnane-3alpha,20alpha-diol recombinant enzyme, at pH 7.4 and 25°C Homo sapiens
0.002
-
 5alpha-Androstan-3alpha-ol-17-one native enzyme, at pH 7.4 and 25°C Homo sapiens
0.0022
-
 5alpha-Androstan-3alpha-ol-17-one recombinant enzyme, at pH 7.4 and 25°C Homo sapiens
0.14
-
 (S)-1,2,3,4-tetrahydronaphth-1-ol recombinant enzyme, at pH 7.4 and 25°C Homo sapiens
0.208
-
 9alpha,11beta-prostaglandin F2 native enzyme, at pH 7.4 and 25°C Homo sapiens
0.22
-
 9alpha,11beta-prostaglandin F2 recombinant enzyme, at pH 7.4 and 25°C Homo sapiens
0.26
-
 (S)-1,2,3,4-tetrahydronaphth-1-ol native enzyme, at pH 7.4 and 25°C Homo sapiens
0.49
-
 (S)-indan-1-ol recombinant enzyme, at pH 7.4 and 25°C Homo sapiens
0.52
-
 (S)-indan-1-ol native enzyme, at pH 7.4 and 25°C Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
36000
-
 x * 36000, SDS-PAGE Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(S)-1,2,3,4-tetrahydronaphth-1-ol + NADP+
-
 Homo sapiens 1,2,3,4-tetrahydronaphth-1-one + NADPH + H+
-
 ?
(S)-indan-1-ol + NADP+
-
 Homo sapiens indan-1-one + NADPH + H+
-
 ?
5alpha-androstan-3alpha-ol-17-one + NADP+
-
 Homo sapiens (5alpha)-androstan-3,17-dione + NADPH + H+
-
 ?
5beta-pregnane-3alpha,20alpha-diol + NADP+
-
 Homo sapiens (5beta)-pregnan-20alpha-ol-3-one + NADPH + H+
-
 ?
9alpha,11beta-prostaglandin F2 + NADP+
-
 Homo sapiens ? + NADPH + H+
-
 ?

Subunits

Subunits Comment Organism
? x * 36000, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
AKR1C2 isoform Homo sapiens
DD2
-
 Homo sapiens
dihydrodiol dehydrogenase
-
 Homo sapiens

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.002
-
 5beta-pregnane-3alpha,20alpha-diol recombinant enzyme, at pH 7.4 and 25°C Homo sapiens
0.003
-
 5beta-pregnane-3alpha,20alpha-diol native enzyme, at pH 7.4 and 25°C Homo sapiens
0.007
-
 5alpha-Androstan-3alpha-ol-17-one native enzyme, at pH 7.4 and 25°C Homo sapiens
0.007
-
 5alpha-Androstan-3alpha-ol-17-one recombinant enzyme, at pH 7.4 and 25°C Homo sapiens
0.083
-
 9alpha,11beta-prostaglandin F2 recombinant enzyme, at pH 7.4 and 25°C Homo sapiens
0.16
-
 (S)-indan-1-ol native enzyme, at pH 7.4 and 25°C Homo sapiens
0.18
-
 (S)-indan-1-ol recombinant enzyme, at pH 7.4 and 25°C Homo sapiens
0.2
-
 (S)-1,2,3,4-tetrahydronaphth-1-ol recombinant enzyme, at pH 7.4 and 25°C Homo sapiens
0.27
-
 (S)-1,2,3,4-tetrahydronaphth-1-ol native enzyme, at pH 7.4 and 25°C Homo sapiens
0.42
-
 9alpha,11beta-prostaglandin F2 native enzyme, at pH 7.4 and 25°C Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NAD+
-
 Homo sapiens
NADP+
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00006
-
 recombinant enzyme, at pH 7.4 and 25°C Homo sapiens Ursodeoxycholic acid
0.00007
-
 native enzyme, at pH 7.4 and 25°C Homo sapiens lithocholic acid
0.00008
-
 native enzyme, at pH 7.4 and 25°C Homo sapiens Ursodeoxycholic acid
0.00008
-
 recombinant enzyme, at pH 7.4 and 25°C Homo sapiens lithocholic acid
0.00013
-
 native enzyme, at pH 7.4 and 25°C Homo sapiens chenodeoxycholic acid
0.00015
-
 recombinant enzyme, at pH 7.4 and 25°C Homo sapiens chenodeoxycholic acid
0.0007
-
 recombinant enzyme, at pH 7.4 and 25°C Homo sapiens Flufenamic acid
0.0009
-
 native enzyme, at pH 7.4 and 25°C Homo sapiens Flufenamic acid
0.0016
-
 recombinant enzyme, at pH 7.4 and 25°C Homo sapiens Medroxyprogesterone acetate
0.0017
-
 native enzyme, at pH 7.4 and 25°C Homo sapiens Medroxyprogesterone acetate
0.0028
-
 native enzyme, at pH 7.4 and 25°C Homo sapiens Hexestrol
0.0035
-
 recombinant enzyme, at pH 7.4 and 25°C Homo sapiens Hexestrol
0.0069
-
 native enzyme, at pH 7.4 and 25°C Homo sapiens Ibuprofen
0.01
-
 recombinant enzyme, at pH 7.4 and 25°C Homo sapiens Ibuprofen
0.012
-
 native enzyme, at pH 7.4 and 25°C Homo sapiens Phenolphthalein
0.018
-
 recombinant enzyme, at pH 7.4 and 25°C Homo sapiens Phenolphthalein
0.07
-
 recombinant enzyme, at pH 7.4 and 25°C Homo sapiens indomethacin
0.075
-
 native enzyme, at pH 7.4 and 25°C Homo sapiens indomethacin