Cloned (Comment) | Organism |
---|---|
expressed in Huh-7 and Hep-G2 cells | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
7alpha,12alpha-dihydroxy-5beta-cholestan-3-one + NAD(P)+ | Homo sapiens | - |
3alpha,7alpha,12alpha-trihydroxy-5beta-cholestane + NAD(P)H + H+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
7alpha,12alpha-dihydroxy-5beta-cholestan-3-one + NAD(P)+ | - |
Homo sapiens | 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestane + NAD(P)H + H+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
3alpha-hydroxysteroid dehydrogenase | - |
Homo sapiens |
AKR1C4 | isoform | Homo sapiens |
type I 3alpha-HSD | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | - |
Homo sapiens | |
NADP+ | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | liver X receptor alpha binds specifically to the liver X receptor alpha response element and mediates transcriptional activation of the AKR1C4 gene. Liver X receptor ligand T1317 induces isoform AKR1C4 expression approximately 2.3fold | up |
General Information | Comment | Organism |
---|---|---|
metabolism | 3alpha-hydroxysteroid dehydrogenase isoform AKR1C4 plays a significant role in bile acid biosynthesis, steroid hormone metabolism, and xenobiotic metabolism | Homo sapiens |