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Literature summary for 1.1.1.351 extracted from

  • Kiriuchin, M.; Kletsova, L.; Chistoserdov, A.; Tsygankov, Y.
    Properties of glucose 6-phosphate and 6-phosphogluconate dehydrogenases of the obligate methylotroph Methylobacillus flagellatum KT (1988), FEMS Microbiol. Lett., 52, 199-204.
No PubMed abstract available

Inhibitors

Inhibitors Comment Organism Structure
ATP 70-85% residual activity at 10 mM Methylobacillus flagellatus
D-ribulose 5-phosphate 60% residual activity at 2 mM Methylobacillus flagellatus
NADH 30-40% residual activity at 0.2 mM, the enzyme is inhibited by NADH and NADPH to a similar extend Methylobacillus flagellatus
NADPH 25-35% residual activity at 0.2 mM, the enzyme is inhibited by NADH and NADPH to a similar extend Methylobacillus flagellatus

Organism

Organism UniProt Comment Textmining
Methylobacillus flagellatus
-
-
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.07
-
with NADP+ as cosubstrate, at 30°C and pH 8.0 Methylobacillus flagellatus
0.67
-
with NAD+ as cosubstrate, at 30°C and pH 8.0 Methylobacillus flagellatus

Storage Stability

Storage Stability Organism
4°C, 30 days, no loss of activity Methylobacillus flagellatus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6-phospho-D-gluconate + NADP+
-
Methylobacillus flagellatus D-ribulose 5-phosphate + CO2 + NADPH + H+
-
?
6-phospho-D-gluconate + NADP+
-
Methylobacillus flagellatus KT1 D-ribulose 5-phosphate + CO2 + NADPH + H+
-
?

Synonyms

Synonyms Comment Organism
6-phosphogluconate dehydrogenase
-
Methylobacillus flagellatus
gnd
-
Methylobacillus flagellatus

Cofactor

Cofactor Comment Organism Structure
NAD+ the enzyme is specific to both to NAD+ and NADP+ Methylobacillus flagellatus
NADP+ the enzyme is specific to both to NAD+ and NADP+ Methylobacillus flagellatus

pI Value

Organism Comment pI Value Maximum pI Value
Methylobacillus flagellatus isoelectric focusing
-
6.5