Any feedback?
Literature summary for 1.1.1.35 extracted from
- Roles of type 10 17beta-hydroxysteroid dehydrogenase in intracrinology and metabolism of isoleucine and fatty acids (2006), Endocr. Metab. Immune Disord. Drug Targets, 6, 95-102.
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| mitochondrion | - |
Homo sapiens | 5739 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 17beta-estradiol + NAD+ | Homo sapiens | inactivation | estrone + NADH + H+ | - |
? |  |
| 5alpha-androstane-3,17-diol + NAD+ | Homo sapiens | inactivation | 5alpha-dihydrotestosterone + NADH | - |
? | |
| allopregnanolone + NAD+ | Homo sapiens | inactivation | 5alpha-dihydroprogesterone + NADH | - |
? | |
| additional information | Homo sapiens | the enzyme is involved in intracrinology and is essential for the metabolism of isoleucine and branched-chain fatty acids | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| astrocyte | activated, high level expression | Homo sapiens | - |
| brain | - |
Homo sapiens | - |
| heart | - |
Homo sapiens | - |
| liver | - |
Homo sapiens | - |
| additional information | wide tissue distribution | Homo sapiens | - |
| prostate | - |
Homo sapiens | - |
| prostate cancer cell | high level expression in malignant prostatic epithelial cells | Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 17beta-estradiol + NAD+ | - |
Homo sapiens | estrone + NADH + H+ | - |
? | |
| 17beta-estradiol + NAD+ | inactivation | Homo sapiens | estrone + NADH + H+ | - |
? | |
| 5alpha-androstane-3,17-diol + NAD+ | - |
Homo sapiens | 5alpha-dihydrotestosterone + NADH | - |
? | |
| 5alpha-androstane-3,17-diol + NAD+ | inactivation | Homo sapiens | 5alpha-dihydrotestosterone + NADH | - |
? | |
| allopregnanolone + NAD+ | - |
Homo sapiens | 5alpha-dihydroprogesterone + NADH | - |
? | |
| allopregnanolone + NAD+ | inactivation | Homo sapiens | 5alpha-dihydroprogesterone + NADH | - |
? | |
| additional information | the enzyme is involved in intracrinology and is essential for the metabolism of isoleucine and branched-chain fatty acids | Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| 17beta-HSD10 | - |
Homo sapiens |
| L-3-hydroxyacyl-CoA dehydrogenase | - |
Homo sapiens |
| SCHSD | - |
Homo sapiens |
| short-chain L-3-hydroxyacyl-CoA dehydrogenase | - |
Homo sapiens |
| type 10 17beta-hydroxysteroid dehydrogenase | - |
Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NAD+ | - |
Homo sapiens | |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
