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Literature summary for 1.1.1.35 extracted from

  • He, X.Y.; Merz, G.; Mehta, P.; Schulz, H.; Yang, S.Y.
    Human brain short chain L-3-hydroxyacyl Coenzyme A dehydrogenase is a singl-domain multifunctional enzyme (1999), J. Biol. Chem., 274, 15014-15019.
    View publication on PubMed
Search for more literature for 1.1.1.35

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.034
-
 (3beta,5alpha,17beta)-androstane-3,17-diol enzyme from brain Homo sapiens
0.043
-
 17beta-estradiol enzyme from brain Homo sapiens
0.045
-
 androsterone enzyme from brain Homo sapiens
0.05
-
 NAD+ enzyme from brain, substrate 17beta-estradiol Homo sapiens
0.21
-
 NAD+ enzyme from brain, substrate dihydroandrosterone Homo sapiens
0.242
-
 NAD+ enzyme from brain, substrate androsterone Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum
-
 Homo sapiens 5783
-
mitochondrion
-
 Homo sapiens 5739
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(S)-3-hydroxybutyryl-CoA + NAD+ Homo sapiens
-
 acetoacetyl-CoA + NADH
-
 r
17beta-estradiol + NAD+ Homo sapiens enzyme conatains 17beta-hydroxysteroid and 3alpha-hydroxysteroid dehydrogenase activity estrone + NADH + H+
-
 ir

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.002
-
 enzyme from brain, substrate 1-propanol Homo sapiens
0.0121
-
 enzyme from brain, substrate androsterone Homo sapiens
0.0156
-
 enzyme from brain, substrate 17beta-estradiol Homo sapiens
0.087
-
 enzyme from brain, substrate 5alpha-dihydrotestosterone Homo sapiens
0.13
-
 enzyme from brain, substrate dihydroandrosterone Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(S)-3-hydroxybutyryl-CoA + NAD+
-
 Homo sapiens acetoacetyl-CoA + NADH
-
 r
1-propanol + NAD+ multifunctional enzyme from brain Homo sapiens n-propanal + NADH
-
 ir
17beta-estradiol + NAD+ enzyme from brain contains 17beta-hydroxysteroid and 3alpha-hydroxysteroid dehydrogenase activity Homo sapiens estrone + NADH + H+
-
 ir
17beta-estradiol + NAD+ enzyme conatains 17beta-hydroxysteroid and 3alpha-hydroxysteroid dehydrogenase activity Homo sapiens estrone + NADH + H+
-
 ir
2-propanol + NAD+ multifunctional enzyme from brain Homo sapiens acetone + NADH
-
 ir
5alpha-dihydrotestosterone + NADH
-
 Homo sapiens (3beta,5alpha,17beta)-androstane-3,17-diol + NAD+
-
 r
androsterone + NAD+
-
 Homo sapiens androstanedione + NADH
-
 ir

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.011
-
 androsterone enzyme from brain Homo sapiens
0.011
-
 17beta-estradiol enzyme from brain Homo sapiens
0.093
-
 (3beta,5alpha,17beta)-androstane-3,17-diol enzyme from brain Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.5 7 enzyme from brain, reduction of acetoacetyl-CoA Homo sapiens
9.5 10 enzyme from brain, oxidation of 17beta-estradiol Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NAD+
-
 Homo sapiens