Cloned (Comment) | Organism |
---|---|
gene HMGR, DNA and amino acid sequence determination and analysis, sequence comparisons and phylogenetic analysis, subcloning in Escherichia coli strain DH5alpha | Centella asiatica |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
58000 | - |
x * 58000, about, sequence calculation | Centella asiatica |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
(R)-mevalonate + CoA + 2 NADP+ | Centella asiatica | - |
(S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+ | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Centella asiatica | W6APW1 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
leaf | - |
Centella asiatica | - |
additional information | the enzyme shows a strong expression in nodes followed by leaves and stem. Roots record the lowest expression level among all the tissues tested | Centella asiatica | - |
node | - |
Centella asiatica | - |
root | - |
Centella asiatica | - |
stem | - |
Centella asiatica | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(R)-mevalonate + CoA + 2 NADP+ | - |
Centella asiatica | (S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+ | - |
r |
Subunits | Comment | Organism |
---|---|---|
? | x * 58000, about, sequence calculation | Centella asiatica |
Synonyms | Comment | Organism |
---|---|---|
3-hydroxy-3-methylglutaryl coenzyme A reductase | - |
Centella asiatica |
HMGR | - |
Centella asiatica |
Organism | Comment | pI Value Maximum | pI Value |
---|---|---|---|
Centella asiatica | sequence calculation | - |
8.65 |
General Information | Comment | Organism |
---|---|---|
additional information | structure-function analysis of HMGR, homology modelling using human HMGR, PDB ID 1DQ8A, as template, overview | Centella asiatica |
physiological function | the enzyme plays an important role in catalyzing the first committed step of isoprenoid biosynthesis in the mevalonic acid pathway catalyzing the conversion of HMG-CoA to mevalonic acid in plants | Centella asiatica |