Literature summary for 1.1.1.34 extracted from

Sashidhara, K.V.; Singh, S.P.; Srivastava, A.; Puri, A.; Chhonker, Y.S.; Bhatta, R.S.; Shah, P.; Siddiqi, M.I.
Discovery of a new class of HMG-CoA reductase inhibitor from Polyalthia longifolia as potential lipid lowering agent (2011), Eur. J. Med. Chem., 46, 5206-5211.

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Inhibitors

Inhibitors	Comment	Organism	Structure
(5S)-5-hydroxy-4-{2-[(1S,2R,4aR)-1,2,4a,5-tetramethyl-1,2,3,4,4a,7,8,8a-octahydronaphthalen-1-yl]ethyl}furan-2(5H)-one	22.65% inhibition of HMG-CoA reductase at 0.001 mM concentration and maximum inhibition of 78.03% at 0.1 mM, the HMG-CoA reductase inhibitor, a clerodane diterpene from ethanolic extract of Polyalthia longifolia var. pendula, is a potential lipid lowering agent, molecular docking analysis, overview	Mesocricetus auratus
lovastatin	the representative of the statin class of drugs that in their active hydrolysed form are specific inhibitors of the enzyme	Mesocricetus auratus

Organism

Organism	UniProt	Comment	Textmining
Mesocricetus auratus	-	-	-

Synonyms

Synonyms	Comment	Organism
3-hydroxy-3-methylglutaryl co-enzyme A reductase	-	Mesocricetus auratus
HMG-CoA reductase	-	Mesocricetus auratus
HMGR	-	Mesocricetus auratus

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Release 2023.1 (January 2023)