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Literature summary for 1.1.1.34 extracted from

  • Subbaiah, P.V.; Sowa, J.M.; Singh, D.K.
    Sphingolipids and cellular cholesterol homeostasis. Effect of ceramide on cholesterol trafficking and HMG CoA reductase activity (2008), Arch. Biochem. Biophys., 474, 32-38.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.1.1.34

Activating Compound

Activating Compound Comment Organism Structure
additional information phosphorylation of HMGCR is stimulated by SMase C or exogenous ceramide Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
ceramide treatment with exogenous ceramides, or increasing the endogenous ceramide levels inhibits HMGCR by 60–80% Homo sapiens
SMase C treatment of fibroblasts with SMase C results in a 90% inhibition of HMGCR Homo sapiens
SMase D treatment of fibroblasts with SMase D inhibits by 29% Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
fibroblast
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
mevaldehyde + NADPH + H+
-
 Homo sapiens (R)-mevalonate + NADP+
-
 ?

Synonyms

Synonyms Comment Organism
HMG CoA reductase
-
 Homo sapiens
HMGCR
-
 Homo sapiens