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Literature summary for 1.1.1.34 extracted from

  • Pak, V.V.; Koo, M.; Kim, M.J.; Yang, H.J.; Yun, L.; Kwon, D.Y.
    Modeling an active conformation for linear peptides and design of a competitive inhibitor for HMG-CoA reductase (2008), J. Mol. Recognit., 21, 224-232.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
GFPTGG competitive, effects on enzyme Michaelis-Menten kinetics, overview Rattus norvegicus
GLPTGG competitive Rattus norvegicus
additional information design, synthesis and evaluation of structure-based peptide inhibitors, computational methods, overview Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.068
-
hydroxymethylglutaryl-CoA
-
Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
Rattus norvegicus
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
hydroxymethylglutaryl-CoA + NADPH + H+ Rattus norvegicus
-
mevalonate + NADP+ + CoA
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
hydroxymethylglutaryl-CoA + NADPH + H+
-
Rattus norvegicus mevalonate + NADP+ + CoA
-
?

Synonyms

Synonyms Comment Organism
HMG-CoA reductase
-
Rattus norvegicus
HMGR
-
Rattus norvegicus

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.023
-
hydroxymethylglutaryl-CoA
-
Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
NADPH
-
Rattus norvegicus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0064
-
GFPTGG
-
Rattus norvegicus