Cloned (Comment) | Organism |
---|---|
expression in Escherichia coli | Haloferax volcanii |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(R)-3-hydroxy-3-methylglutaryl-CoA | competitive inhibitor | Haloferax volcanii | |
lovastatin | - |
Haloferax volcanii |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.03 | - |
CoA | - |
Haloferax volcanii | |
0.032 | - |
NADPH | reduction of R,S-mevaldehyde | Haloferax volcanii | |
0.035 | - |
NADP+ | - |
Haloferax volcanii | |
0.06 | - |
(S)-3-hydroxy-3-methylglutaryl-CoA | - |
Haloferax volcanii | |
0.066 | - |
NADPH | - |
Haloferax volcanii | |
0.47 | - |
(R,S)-mevaldehyde | oxidative acylation of (R,S)-mevaldehyde | Haloferax volcanii | |
0.55 | - |
(R,S)-mevaldehyde | reduction of (R,S)-mevaldehyde | Haloferax volcanii |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
3-hydroxy-3-methylglutaryl-CoA + NADPH | Haloferax volcanii | - |
(R)-mevalonate + CoA + NADP+ | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Haloferax volcanii | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Haloferax volcanii |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
24000 | - |
- |
Haloferax volcanii |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(R,S)-mevaldehyde + acetate | - |
Haloferax volcanii | ? | - |
? | |
(R,S)-mevaldehyde + NADPH | - |
Haloferax volcanii | ? | - |
? | |
(S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+ | - |
Haloferax volcanii | (R)-mevalonate + 2 NADP+ + CoA | - |
? | |
3-hydroxy-3-methylglutaryl-CoA + NADPH | - |
Haloferax volcanii | (R)-mevalonate + CoA + NADP+ | - |
r |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
6 | - |
reduction of (R,S)-mevaldehyde | Haloferax volcanii |
7.3 | - |
- |
Haloferax volcanii |
8 | - |
oxidative acylation of (R,S)-mevaldehyde | Haloferax volcanii |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | - |
Haloferax volcanii |