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Literature summary for 1.1.1.337 extracted from

  • Graupner, M.; White, R.H.
    The first examples of (S)-2-hydroxyacid dehydrogenases catalyzing the transfer of the pro-4S hydrogen of NADH are found in the archaea (2001), Biochim. Biophys. Acta, 158, 169-173.
    View publication on PubMed

Organism

Organism UniProt Comment Textmining
Methanocaldococcus jannaschii Q58820
-
-
Methanothermus fervidus P16142
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-oxoglutarate + NADH + H+
-
Methanocaldococcus jannaschii (S)-2-hydroxyglutarate + NAD+
-
?
additional information enzyme catalyzes the NADH-dependent reduction of oxaloacetate, 2-oxoglutarate, and pyruvate to the corresponding (S)-2-hydroxyacids with pro-S NADH-stereospecificity Methanocaldococcus jannaschii ?
-
?
oxaloacetate + NADH + H+ transfer of pro-4S hydrogen from the reduced coenzyme to the 2-oxoacid substrate Methanocaldococcus jannaschii (S)-malate + NAD+
-
?
oxaloacetate + NADH + H+ transfer of pro-4S hydrogen from the reduced coenzyme to the 2-oxoacid substrate Methanothermus fervidus (S)-malate + NAD+
-
?
pyruvate + NADH + H+
-
Methanocaldococcus jannaschii (S)-lactate + NAD+
-
?

Synonyms

Synonyms Comment Organism
MDH I
-
Methanocaldococcus jannaschii
MDH I
-
Methanothermus fervidus
MJ1425
-
Methanocaldococcus jannaschii

Cofactor

Cofactor Comment Organism Structure
NADH
-
Methanothermus fervidus