Literature summary for 1.1.1.330 extracted from

Han, G.; Gable, K.; Kohlwein, S.; Beaudoin, F.; Napier, J.; Dunn, T.
The Saccharomyces cerevisiae YBR159w gene encodes the 3-ketoreductase of the microsomal fatty acid elongase (2002), J. Biol. Chem., 277, 35440-35449.

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Organism

Organism	UniProt	Comment	Textmining
Saccharomyces cerevisiae	P38286	-	-

Synonyms

Synonyms	Comment	Organism
ybr159	-	Saccharomyces cerevisiae

General Information

General Information	Comment	Organism
physiological function	a Ybr159 gene disruption mutant shows reduced very long-chain fatty acid synthesis, accumulation of high levels of dihydrosphingosine and phytosphingosine, and accumulation of medium-chain ceramides. Mutant is deficient in the reduction of the 3-ketoacyl intermediates of fatty acid elongation. The mutant also displays reduced dehydration of the 3-OH acyl intermediates of fatty acid elongation, suggesting that its gene is required for the stability or function of the dehydratase activity of the elongase system. The enzyme protein co-localizes and co-immunoprecipitates with other elongating enzymes, Elo3p and Tsc13p. Whereas very long-chain fatty acid synthesis is essential for viability, the deletion mutant cells are viable albeit very slowly growing and do synthesize some very long-chain fatty acids. A ybr159ayr1 double mutant is inviable, suggesting that Ayr1p is responsible for the residual 3-ketoreductase activity	Saccharomyces cerevisiae

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Release 2023.1 (January 2023)