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Literature summary for 1.1.1.300 extracted from

  • Kanan, Y.; Wicker, L.D.; Al-Ubaidi, M.R.; Mandal, N.A.; Kasus-Jacobi, A.
    Retinol dehydrogenases RDH11 and RDH12 in the mouse retina: expression levels during development and regulation by oxidative stress (2008), Invest. Ophthalmol. Vis. Sci., 49, 1071-1078.
    View publication on PubMedView publication on EuropePMC
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus the low and constant expression of RDH11 suggests a housekeeping function for this enzyme in retina ?
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 ?
additional information Mus musculus the onset of RDH12 expression during the maturation of photoreceptor cells suggests a function related to the visual process. The light-induced rapid decrease of RDH12 protein, preceding the decrease of the mRNA, suggested a specific degradation of the protein rather than a regulation of gene expression ?
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 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
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 isoforms Rdh11, Rdh12
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Mus musculus Q8BYK4
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Mus musculus Q9QYF1
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Source Tissue

Source Tissue Comment Organism Textmining
retina level of isoform Rdh11 is low and remarkably constant during development and oxidative stress. Rdh12 expression starts at postnatal day 7 and increases until postnatal day 30 to approximately sevenfold higher than Rdh11. Oxidative stress induced by exposure to constant bright light leads to a rapid and significant decrease of Rdh12 protein Mus musculus
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retina RDH12 expression starts at postnatal day and increases until postnatal day 30. Oxidative stress induced by exposure to constant bright light leads to a rapid and significant decrease of RDH12 protein Mus musculus
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retina the RDH11 level is low and remarkably constant during development and oxidative stress Mus musculus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the low and constant expression of RDH11 suggests a housekeeping function for this enzyme in retina Mus musculus ?
-
 ?
additional information the onset of RDH12 expression during the maturation of photoreceptor cells suggests a function related to the visual process. The light-induced rapid decrease of RDH12 protein, preceding the decrease of the mRNA, suggested a specific degradation of the protein rather than a regulation of gene expression Mus musculus ?
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 ?

Synonyms

Synonyms Comment Organism
RDH11
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 Mus musculus
RDH12
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 Mus musculus