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Literature summary for 1.1.1.300 extracted from
- Dual-substrate specificity short chain retinol dehydrogenases from the vertebrate retina (2002), J. Biol. Chem., 277, 45537-45546.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 9-cis-retinoic acid | - |
Homo sapiens |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 11-cis-retinol + NADP+ | Homo sapiens | possibly involved in the production of 11-cis-retinal from 11-cis-retinol during regeneration of the cone visual pigments | 11-cis-retinal + NADPH + H+ | - |
r | |
| 9-cis-retinol + NADP+ | Homo sapiens | possibly involved in the first step of 9-cis-retinoic acid production | 9-cis-retinal + NADPH + H+ | - |
r | |
| all-trans-retinol + NADP+ | Homo sapiens | possibly involved in the first step of all-trans-retinoic acid production | all-trans-retinal + NADPH + H+ | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
recombinant enzyme | - |
| Homo sapiens | Q96NR8 | - |
- |
| Homo sapiens | Q96NR8 | recombinant enzyme | - |
| Homo sapiens | Q9HBH5 | recombinant enzyme | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Homo sapiens | - |
| eye | - |
Homo sapiens | - |
| eye | photoreceptor nuclear layer | Homo sapiens | - |
| kidney | - |
Homo sapiens | - |
| pancreas | - |
Homo sapiens | - |
| photoreceptor | - |
Homo sapiens | - |
| placenta | - |
Homo sapiens | - |
| retinal pigment epithelial cell | - |
Homo sapiens | - |
| skeletal muscle | - |
Homo sapiens | - |
| stomach | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 11-cis-retinal + NADPH + H+ | - |
Homo sapiens | 11-cis-retinol + NADP+ | - |
r | |
| 11-cis-retinol + NADP+ | possibly involved in the production of 11-cis-retinal from 11-cis-retinol during regeneration of the cone visual pigments | Homo sapiens | 11-cis-retinal + NADPH + H+ | - |
r | |
| 13-cis-retinal + NADPH | - |
Homo sapiens | 13-cis-retinol + NADP+ | - |
r | |
| 9-cis-retinal + NADPH | - |
Homo sapiens | 9-cis-retinol + NADP+ | - |
r | |
| 9-cis-retinol + NADP+ | possibly involved in the first step of 9-cis-retinoic acid production | Homo sapiens | 9-cis-retinal + NADPH + H+ | - |
r | |
| all-trans-retinal + NADPH + H+ | - |
Homo sapiens | all-trans-retinol + NADP+ | - |
r | |
| all-trans-retinol + NADP+ | possibly involved in the first step of all-trans-retinoic acid production | Homo sapiens | all-trans-retinal + NADPH + H+ | - |
? | |
| additional information | clear specificity for pro-S hydrogen of NADPH and for pro-R-hydrogen on C15 of the retinols, no steroid dehydrogenase activity | Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| RDH11 | - |
Homo sapiens |
| RDH12 | - |
Homo sapiens |
| RDH14 | - |
Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NADP+ | - |
Homo sapiens | |
| NADPH | - |
Homo sapiens | |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.001 | - |
9-cis-retinoic acid | pH 7.4 | Homo sapiens | |
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Release 2023.1 (January 2023)
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