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Literature summary for 1.1.1.30 extracted from

  • Tan, A.W.H.; Smith, C.M.; Aogaichi, T.; Plaut, G.W.E.
    Inhibition of D(-)-3-hydroxybutyrate dehydrogenase by malonate analoges (1975), Arch. Biochem. Biophys., 166, 164-173.
    View publication on PubMed
Search for more literature for 1.1.1.30

Activating Compound

Activating Compound Comment Organism Structure
phosphatidylcholine
-
 Cavia porcellus
phosphatidylcholine
-
 Rattus norvegicus
phosphatidylcholine
-
 Bos taurus

Inhibitors

Inhibitors Comment Organism Structure
bromomalonate
-
 Bos taurus
bromomalonate
-
 Cavia porcellus
bromomalonate
-
 Rattus norvegicus
chloromalonate
-
 Bos taurus
chloromalonate
-
 Cavia porcellus
chloromalonate
-
 Rattus norvegicus
dimethylmalonate 15.3 mM, 50% inhibition, oxidation, 11.3% reduction Bos taurus
dimethylmalonate 7.6 mM, 50% inhibition, oxidation, 8.5 mM, reduction Cavia porcellus
Hydroxymalonate 4.8 mM, 50% inhibition, oxidation, 7.8 reduction Bos taurus
Hydroxymalonate 1.8 mM, 50% inhibition, oxidation, 6.0 mM, reduction Cavia porcellus
Hydroxymalonate
-
 Rattus norvegicus
malonate 9.5 mM, 50% inhibition, oxidation, 8.2 mM Bos taurus
malonate 3.7 mM, 50% inhibition, oxidation Cavia porcellus
malonate
-
 Rattus norvegicus
mesoxalate
-
 Bos taurus
mesoxalate
-
 Cavia porcellus
mesoxalate
-
 Rattus norvegicus
methylmalonate 2.1 mM, 50% inhibition, oxidation Bos taurus
methylmalonate 1.4 mM, 50% inhibition, oxidation, 0.8 mM reduction Cavia porcellus
methylmalonate
-
 Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(R)-3-hydroxybutanoate + NAD+ Cavia porcellus
-
 acetoacetate + NADH
-
 r
(R)-3-hydroxybutanoate + NAD+ Rattus norvegicus
-
 acetoacetate + NADH
-
 r
(R)-3-hydroxybutanoate + NAD+ Bos taurus
-
 acetoacetate + NADH
-
 r

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-
Cavia porcellus
-
-
-
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
heart
-
 Cavia porcellus
-
heart
-
 Rattus norvegicus
-
heart
-
 Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(R)-3-hydroxybutanoate + NAD+
-
 Cavia porcellus acetoacetate + NADH
-
 r
(R)-3-hydroxybutanoate + NAD+
-
 Rattus norvegicus acetoacetate + NADH
-
 r
(R)-3-hydroxybutanoate + NAD+
-
 Bos taurus acetoacetate + NADH
-
 r

Cofactor

Cofactor Comment Organism Structure
NAD+
-
 Cavia porcellus
NAD+
-
 Rattus norvegicus
NAD+
-
 Bos taurus