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Literature summary for 1.1.1.3 extracted from

  • Saiki, T.; Shinshi, H.; Arima, K.
    Studies on homoserine dehydrogenase from an extreme thermophile, Thermus flavus AT-62. Partial purification and properties (1973), J. Biochem., 74, 1239-1248.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
L-threonine not inhibitory Thermus thermophilus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.17 0.18 NADP+
-
Thermus thermophilus

Metals/Ions

Metals/Ions Comment Organism Structure
K+ activation Thermus thermophilus
Na+ activation Thermus thermophilus

Organism

Organism UniProt Comment Textmining
Thermus thermophilus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
partial Thermus thermophilus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-aspartate 4-semialdehyde + NAD(P)H
-
Thermus thermophilus L-homoserine + NAD(P)+
-
r
L-homoserine + NAD(P)+
-
Thermus thermophilus L-aspartate 4-semialdehyde + NAD(P)H
-
r

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
additional information
-
above 50°C temperature dependent conformational change Thermus thermophilus

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
70
-
up to Thermus thermophilus
80
-
slow inactivation, protection by K+, Na+ Thermus thermophilus
90
-
rapid inactivation Thermus thermophilus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
9
-
-
Thermus thermophilus