Literature summary for 1.1.1.3 extracted from

Wedler, F.C.; Ley, B.W.
Kinetic and regulatory mechanisms for (Escherichia coli) homoserine dehydrogenase-I (1993), J. Biol. Chem., 268, 4880-4888.

Search for more literature for 1.1.1.3

Inhibitors

Inhibitors	Comment	Organism	Structure
L-threonine	-	Escherichia coli

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.013	-	L-homoserine	-	Escherichia coli
0.073	-	NADP+	-	Escherichia coli
0.09	-	NADPH	-	Escherichia coli
0.17	-	L-aspartate 4-semialdehyde	-	Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
L-aspartate 4-semialdehyde + NAD(P)H	Escherichia coli	kinetic mechanism	L-homoserine + NAD(P)+	-	r

Organism

Organism	UniProt	Comment	Textmining
Escherichia coli	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
L-aspartate 4-semialdehyde + NAD(P)H	-	Escherichia coli	L-homoserine + NAD(P)+	-	r
L-aspartate 4-semialdehyde + NAD(P)H	kinetic mechanism	Escherichia coli	L-homoserine + NAD(P)+	-	r
L-homoserine + NAD(P)+	-	Escherichia coli	L-aspartate 4-semialdehyde + NAD(P)H	-	r

Cofactor

Cofactor	Comment	Organism	Structure
NADP+	-	Escherichia coli
NADPH	-	Escherichia coli

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Release 2023.1 (January 2023)