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Literature summary for 1.1.1.284 extracted from

  • Sanghani, P.C.; Davis, W.I.; Fears, S.L.; Green, S.L.; Zhai, L.; Tang, Y.; Martin, E.; Bryan, N.S.; Sanghani, S.P.
    Kinetic and cellular characterization of novel inhibitors of S-nitrosoglutathione reductase (2009), J. Biol. Chem., 284, 24354-24362.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.1.1.284

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
3-[1-(4-acetylphenyl)-5-phenyl-1H-pyrrol-2-yl]propanoic acid exhibits noncompetitive or uncompetitive inhibition against varied concentrations of S-nitrosoglutathione or NADH Homo sapiens
3-[1-(4-acetylphenyl)-5-phenyl-1H-pyrrol-2-yl]propanoic acid 3-[1-(4-acetylphenyl)-5-phenyl-1H-pyrrol-2-yl]propanoic acid and 4-([2-[(2-cyanobenzyl)sulfanyl]-4-oxothieno[3,2-d]pyrimidin-3(4H)-yl]methyl)benzoic acid are more effective than 5-chloro-3-[2-[(4-ethoxyphenyl)(ethyl)amino]-2-oxoethyl]-1H-indole-2-carboxylic acid in inhibiting GSNOR inside the cells, dependence of S-nitrosothiols accumulation on the concentration of compound Mus musculus
4-([2-[(2-cyanobenzyl)sulfanyl]-4-oxothieno[3,2-d]pyrimidin-3(4H)-yl]methyl)benzoic acid exhibits noncompetitive or uncompetitive inhibition against varied concentrations of S-nitrosoglutathione or NADH Homo sapiens
4-([2-[(2-cyanobenzyl)sulfanyl]-4-oxothieno[3,2-d]pyrimidin-3(4H)-yl]methyl)benzoic acid 3-[1-(4-acetylphenyl)-5-phenyl-1H-pyrrol-2-yl]propanoic acid and 4-([2-[(2-cyanobenzyl)sulfanyl]-4-oxothieno[3,2-d]pyrimidin-3(4H)-yl]methyl)benzoic acid are more effective than 5-chloro-3-[2-[(4-ethoxyphenyl)(ethyl)amino]-2-oxoethyl]-1H-indole-2-carboxylic acid in inhibiting GSNOR inside the cells, dependence of S-nitrosothiols accumulation on the concentration of compound. 4-([2-[(2-cyanobenzyl)sulfanyl]-4-oxothieno[3,2-d]pyrimidin-3(4H)-yl]methyl)benzoic acid increases the nitrosylation of cellular proteins in RAW264.7 cells in a time-dependent manner Mus musculus
5-chloro-3-[2-[(4-ethoxyphenyl)(ethyl)amino]-2-oxoethyl]-1H-indole-2-carboxylic acid exhibits noncompetitive or uncompetitive inhibition against varied concentrations of S-nitrosoglutathione or NADH Homo sapiens
5-chloro-3-[2-[(4-ethoxyphenyl)(ethyl)amino]-2-oxoethyl]-1H-indole-2-carboxylic acid 3-[1-(4-acetylphenyl)-5-phenyl-1H-pyrrol-2-yl]propanoic acid and 4-([2-[(2-cyanobenzyl)sulfanyl]-4-oxothieno[3,2-d]pyrimidin-3(4H)-yl]methyl)benzoic acid are more effective than 5-chloro-3-[2-[(4-ethoxyphenyl)(ethyl)amino]-2-oxoethyl]-1H-indole-2-carboxylic acid in inhibiting GSNOR inside the cells, dependence of S-nitrosothiols accumulation on the concentration of compound Mus musculus
dodecanoic acid noncompetitive inhibition Homo sapiens
additional information GSNOR inhibitors may be novel tools for regulating nitric oxide bioactivity and assessing the role of S-nitrosothiols in vivo Mus musculus

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
RAW-264.7 cell
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-nitrosoglutathione + NADH + H+
-
 Mus musculus ?
-
 ?
S-nitrosoglutathione + NADH + H+
-
 Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
GSNOR
-
 Mus musculus
GSNOR
-
 Homo sapiens
S-nitrosoglutathione reductase
-
 Mus musculus
S-nitrosoglutathione reductase
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NADH
-
 Mus musculus
NADH
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function GSNOR limits nitric oxide-mediated suppression of NF-kappaB and activation of soluble guanylyl cyclase Mus musculus