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Literature summary for 1.1.1.284 extracted from

  • Staab, C.A.; Hellgren, M.; Grafstroem, R.C.; Hoeoeg, J.O.
    Medium-chain fatty acids and glutathione derivatives as inhibitors of S-nitrosoglutathione reduction mediated by alcohol dehydrogenase 3 (2009), Chem. Biol. Interact., 180, 113-118.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
decanedioic acid sebacic acid Homo sapiens
Decanoic acid capric acid Homo sapiens
dodecanedioic acid most efficient inhibitor Homo sapiens
dodecanoic acid lauric acid, most efficient inhibitor, competitively inhibits Homo sapiens
glutathione
-
Homo sapiens
GSSG
-
Homo sapiens
additional information not inhibited by 0.4 mM 2-aminodecanoic acid and 10 mM glutathionesulfonic acid Homo sapiens
Nonanoic acid pelargonic acid Homo sapiens
octanoic acid caprylic acid Homo sapiens
S-acetamidoglutathione
-
Homo sapiens
S-Methylglutathione
-
Homo sapiens
Tridecanoic acid tridecylic acid Homo sapiens
Undecanoic acid undecylic acid, most efficient inhibitor Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Zinc for glutathione-derived ADH3 ligands, a nucleophilic group in coordination distance of the active site zinc is imperative for efficient binding Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
to homogeneity in a three-step procedure Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-nitrosoglutathione + NADH + H+
-
Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
ADH3
-
Homo sapiens
alcohol dehydrogenase 3
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NADH
-
Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.173
-
dodecanedioic acid inhibition of S-nitrosoglutathione reduction Homo sapiens
0.177
-
dodecanoic acid inhibition of S-nitrosoglutathione reduction Homo sapiens
0.19
-
Undecanoic acid inhibition of S-nitrosoglutathione reduction Homo sapiens
0.224
-
Tridecanoic acid inhibition of S-nitrosoglutathione reduction Homo sapiens
0.231
-
Decanoic acid inhibition of S-nitrosoglutathione reduction Homo sapiens
0.437
-
decanedioic acid inhibition of S-nitrosoglutathione reduction Homo sapiens
0.621
-
Nonanoic acid inhibition of S-nitrosoglutathione reduction Homo sapiens
0.909
-
octanoic acid inhibition of S-nitrosoglutathione reduction Homo sapiens
6.1
-
S-acetamidoglutathione inhibition of S-nitrosoglutathione reduction Homo sapiens
15
-
S-Methylglutathione inhibition of S-nitrosoglutathione reduction Homo sapiens
21
-
glutathione inhibition of S-nitrosoglutathione reduction Homo sapiens
50
-
GSSG with 10 and 20 mM, inhibition of S-nitrosoglutathione reduction Homo sapiens