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Literature summary for 1.1.1.28 extracted from

  • Yu, S.; Zhu, L.; Zhou, C.; An, T.; Jiang, B.; Mu, W.
    Enzymatic production of D-3-phenyllactic acid by Pediococcus pentosaceus D-lactate dehydrogenase with NADH regeneration by Ogataea parapolymorpha formate dehydrogenase (2014), Biotechnol. Lett., 36, 627-631.
    View publication on PubMed

Application

Application Comment Organism
synthesis the recombinant enzyme from Pediococcus pentosaceus can be used for production of 3-phenyllactic acid (2-hydroxy-3-phenylpropanoic acid, PLA), an antimicrobial compound with broad spectrum activity against both bacteria and fungi, optimization by coexpression of Ogataea parapolymorpha formate dehydrogenase, EC 1.2.1.2, for NADH regeneration Pediococcus pentosaceus

Cloned(Commentary)

Cloned (Comment) Organism
co-overexpression of Pediococcus pentosaceus D-lactate dehydrogenase and Ogataea parapolymorpha FDH as His6-tagged enzymes in Escherichia coli strain BL21(DE3) Pediococcus pentosaceus

Protein Variants

Protein Variants Comment Organism
additional information enzymatic production of D-3-phenyllactic acid by recombinant Pediococcus pentosaceus D-lactate dehydrogenase with NADH regeneration by recombinant Ogataea parapolymorpha formate dehydrogenase, EC 1.2.1.2, at pH 6.0, 50°C Pediococcus pentosaceus

Inhibitors

Inhibitors Comment Organism Structure
NAD+ inhibits D-3-phenyllactate biotransformation Pediococcus pentosaceus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
D-3-phenylpyruvate + NADH + H+ Pediococcus pentosaceus
-
D-3-phenyllactate + NAD+
-
r
additional information Pediococcus pentosaceus enzymatic production of D-3-phenyllactic acid by recombinant Pediococcus pentosaceus D-lactate dehydrogenase with NADH regeneration by recombinant Ogataea parapolymorpha formate dehydrogenase, EC 1.2.1.2 ?
-
?
pyruvate + NADH + H+ Pediococcus pentosaceus
-
(R)-lactate + NAD+
-
r

Organism

Organism UniProt Comment Textmining
Pediococcus pentosaceus Q9AKS9
-
-

Purification (Commentary)

Purification (Comment) Organism
copurification of recombinant His6-tagged D-lactate dehydrogenase and His6-tagged Ogataea parapolymorpha FDH from Escherichia coli strain BL21(DE3) by nickel affinity chromatography Pediococcus pentosaceus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-3-phenylpyruvate + NADH + H+
-
Pediococcus pentosaceus D-3-phenyllactate + NAD+
-
r
D-3-phenylpyruvate + NADH + H+
-
Pediococcus pentosaceus D-3-phenyllactate + NAD+ i.e. 2-hydroxy-3-phenylpropanoic acid r
additional information enzymatic production of D-3-phenyllactic acid by recombinant Pediococcus pentosaceus D-lactate dehydrogenase with NADH regeneration by recombinant Ogataea parapolymorpha formate dehydrogenase, EC 1.2.1.2 Pediococcus pentosaceus ?
-
?
pyruvate + NADH + H+
-
Pediococcus pentosaceus (R)-lactate + NAD+
-
r

Synonyms

Synonyms Comment Organism
D-LDH
-
Pediococcus pentosaceus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
45
-
-
Pediococcus pentosaceus

Temperature Range [°C]

Temperature Minimum [°C] Temperature Maximum [°C] Comment Organism
35 70 activity range, profile overview Pediococcus pentosaceus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
5.5
-
-
Pediococcus pentosaceus

pH Range

pH Minimum pH Maximum Comment Organism
4 9 activity range, profile overview Pediococcus pentosaceus

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Pediococcus pentosaceus
NADH
-
Pediococcus pentosaceus