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Literature summary for 1.1.1.28 extracted from

  • Findrik, Z.; Poljanac, M.; Vasic-Racki, D.
    Modelling and optimization of the (R)-(+)-3,4-dihydroxyphenyllactic acid production catalyzed with D-lactate dehydrogenase from Lactobacillus leishmannii using genetic algorithm (2005), Chem. Biochem. Eng. Q., 19, 351-358.
No PubMed abstract available

Application

Application Comment Organism
synthesis enzymatic synthesis of (R)-3,4-dihydrixyphenyllactic acid, a pharmacological compound that is used for the treatment of menstrual disorders, menostasis, menorrhalgia, insomnia, blood circulation diseases and Angina pectoris. Regeneration of NADH by formate dehydrogenase system. Use of genetic algorithm as a stochastic optimization method seems to be the best choice for the optimization Lactobacillus leichmannii

Organism

Organism UniProt Comment Textmining
Lactobacillus leichmannii
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-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3,4-dihydroxyphenylpyruvic acid + NADH + H+
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Lactobacillus leichmannii (R)-3,4-dihydroxyphenyllactic acid + NAD+
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?

Cofactor

Cofactor Comment Organism Structure
NADH
-
Lactobacillus leichmannii