Inhibitors | Comment | Organism | Structure |
---|---|---|---|
NADPH | the NAD+:NADPH ratio in cell will determinewhether AKR1C2 makes 5alpha-dihydrotestosterone | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
5alpha-dihydrotestosterone + NADPH + H+ | Homo sapiens | in prostate cells AKR1C2 acts as a 3-ketosteroid reductase to eliminate 5alpha-dihydrotestosterone and prevents activation of androgen receptor. AKR1C2 does not act as an oxidase due to either potent product inhibition by NADPH or because it cannot surmount the oxidative 17beta-hydroxysteroid dehydrogenase present. AKR1C2 is not a source of 5alpha-dihydrotestosterone in PC-3 cells | 5alpha-androstan-3alpha,17beta-diol + NADP+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
PC-3 cell | AKR1C2 is not a source of 5alpha-dihydrotestosterone in PC-3 cells | Homo sapiens | - |
prostate | in primary cultures of epithelial cells, high levels of AKR1C2 transcripts are detected in prostate cancer, but not in cell from normal prostate. In prostate cells AKR1C2 acts as a 3-ketosteroid reductase to eliminate 5alpha-dihydrotestosterone and prevents activation of androgen receptor | Homo sapiens | - |
prostate cancer cell | in primary cultures of epithelial cells, high levels of AKR1C2 transcripts are detected in prostate cancer, but not in cell from normal prostate | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
3alpha-androstanediol + NAD+ | - |
Homo sapiens | 5alpha-dihydrotestosterone + NADH | - |
? | |
5alpha-dihydrotestosterone + NADPH + H+ | - |
Homo sapiens | 5alpha-androstan-3alpha,17beta-diol + NADP+ | - |
? | |
5alpha-dihydrotestosterone + NADPH + H+ | in prostate cells AKR1C2 acts as a 3-ketosteroid reductase to eliminate 5alpha-dihydrotestosterone and prevents activation of androgen receptor. AKR1C2 does not act as an oxidase due to either potent product inhibition by NADPH or because it cannot surmount the oxidative 17beta-hydroxysteroid dehydrogenase present. AKR1C2 is not a source of 5alpha-dihydrotestosterone in PC-3 cells | Homo sapiens | 5alpha-androstan-3alpha,17beta-diol + NADP+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
AKR1C2 | - |
Homo sapiens |
aldo-keto reductase 1C2 | - |
Homo sapiens |
type 3 3alpha-hydroxysteroid dehydrogenase | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | - |
Homo sapiens |