Cloned (Comment) | Organism |
---|---|
expressed in Escherichia coli | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
7-hydroxyflavone | 0.007 mM, 50% inhibition, oxidation of androstandiol | Homo sapiens | |
abietic acid | 0.010 mM, 50% inhibition, oxidation of androstandiol | Homo sapiens | |
biochain A | 0.014 mM, 50% inhibition, reduction of androst-4-ene-3,17-dione, 0.008 mM, oxidation of androstanediol | Homo sapiens | |
chrysin | 0.010 mM, 50% inhibition, oxidation of androstandiol | Homo sapiens | |
coumestrol | 0.005 mM, 50% inhibition, reduction of androst-4-ene-3,17-dione, 0.011 mM, 50% inhibition, oxidation of androstanediol | Homo sapiens | |
kaempferol | 0.008 mM, 50% inhibition, oxidation of androstandiol | Homo sapiens | |
naringenin | 0.010 mM, 50% inhibition, oxidation of androstandiol | Homo sapiens | |
quercetin | 0.009 mM, 50% inhibition, reduction of androst-4-ene-3,17-dione, 0.005 mM, oxidation of androstanediol | Homo sapiens | |
zearalenone | 0.004 mM, 50% inhibition, reduction of androst-4-ene-3,17-dione, 0.002 mM, oxidation of androstanediol | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Homo sapiens | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
5alpha-dihydrotestosterone + NAD+ | Homo sapiens | - |
androstandione + NADH + H+ | - |
r | |
androstandiol + NAD+ | Homo sapiens | - |
androsterone + NADH | - |
r | |
testosterone + NAD+ | Homo sapiens | - |
androst-4-ene-3,17-dione + NADH + H+ | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
adrenal gland | in males | Homo sapiens | - |
corpus luteum | - |
Homo sapiens | - |
mammary gland | - |
Homo sapiens | - |
testis | expressed in Leydig cells | Homo sapiens | - |
uterine endometrium | in females | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
5alpha-dihydrotestosterone + NAD+ | - |
Homo sapiens | androstanedione + NADH + H+ | - |
r | |
5alpha-dihydrotestosterone + NAD+ | - |
Homo sapiens | androstandione + NADH + H+ | - |
r | |
androstandiol + NAD+ | - |
Homo sapiens | androsterone + NADH | - |
r | |
androstanediol + NAD+ | - |
Homo sapiens | androsterone + NADH | - |
r | |
testosterone + NAD+ | - |
Homo sapiens | androst-4-ene-3,17-dione + NADH + H+ | - |
r |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | - |
Homo sapiens |