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Literature summary for 1.1.1.236 extracted from

  • Nakajima, K.; Hashimoto, T.; Yamada, Y.
    Two tropinone reductases with different stereospecificities are short-chain dehydrogenases evolved from a common ancestor (1993), Proc. Natl. Acad. Sci. USA, 90, 9591-9595.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.1.1.236

Cloned(Commentary)

Cloned (Comment) Organism
cDNA coding for TRI and TRII isolated and expressed in Escherichia coli NM522, P29X-encoding gene detected Datura stramonium
P29X-encoding gene detected Atropa belladonna

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
tropinone + NADPH + H+ Datura stramonium
-
 pseudotropine + NADP+
-
 ?
tropinone + NADPH + H+ Atropa belladonna
-
 pseudotropine + NADP+
-
 ?
tropinone + NADPH + H+ Hyoscyamus niger
-
 pseudotropine + NADP+
-
 ?

Organism

Organism UniProt Comment Textmining
Atropa belladonna
-
-
-
Datura stramonium
-
-
-
Hyoscyamus niger
-
-
-
no activity in Nicotiana tabacum
-
 tobacco
-

Purification (Commentary)

Purification (Comment) Organism
-
 Datura stramonium

Source Tissue

Source Tissue Comment Organism Textmining
root
-
 Datura stramonium
-
root
-
 Atropa belladonna
-
root
-
 Hyoscyamus niger
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
tropinone + NADPH + H+
-
 Datura stramonium pseudotropine + NADP+
-
 ?
tropinone + NADPH + H+
-
 Atropa belladonna pseudotropine + NADP+
-
 ?
tropinone + NADPH + H+
-
 Hyoscyamus niger pseudotropine + NADP+
-
 ?