Cloned (Comment) | Organism |
---|---|
recombinant expression of the His6-tagged enzyme in Escherichia coli strain BL21(DE3) | Brucella sp. |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(3S)-3-amino-1-(2,3,4,5,6-pentafluorophenyloxy)-4-(1H-imidazol-4-yl)butan-2-one dihydrochloride | - |
Brucella sp. | |
(3S)-3-amino-1-(2,3,4,5,6-pentafluorophenylthio)-4-(1H-imidazol-4-yl)butan-2-one dihydrochloride | - |
Brucella sp. | |
(3S)-3-amino-1-(4-bromophenoxy)-4-(1H-imidazol-4-yl)butan-2-one dihydrochloride | - |
Brucella sp. | |
(3S)-3-amino-1-(4-bromophenylthio)-4-(1H-imidazol-4-yl)butan-2-one dihydrochloride | - |
Brucella sp. | |
(3S)-3-amino-1-(4-fluorophenoxy)-4-(1H-imidazol-4-yl)butan-2-one dihydrochloride | - |
Brucella sp. | |
(3S)-3-amino-1-(4-fluorophenylthio)-4-(1H-imidazol-4-yl)butan-2-one dihydrochloride | - |
Brucella sp. | |
(3S)-3-amino-1-hydroxy-4-(1H-imidazol-4-yl)butan-2-one dihydrochloride | - |
Brucella sp. | |
(3S)-3-amino-1-thio-4-(1H-imidazol-4-yl)butan-2-one dihydrochloride | - |
Brucella sp. | |
(3S)-3-amino-4-(1H-imidazol-4-yl)-1-(naphthalen-2-yloxy)butan-2-one dihydrochloride | - |
Brucella sp. | |
(3S)-3-amino-4-(1H-imidazol-4-yl)-1-(naphthalen-2-ylthio)butan-2-one dihydrochloride | - |
Brucella sp. | |
(3S)-3-amino-4-(1H-imidazol-4-yl)-1-(p-tolyloxy)butan-2-one dihydrochloride | - |
Brucella sp. | |
(3S)-3-amino-4-(1H-imidazol-4-yl)-1-(phenyloxy)butan-2-one dihydrochloride | - |
Brucella sp. | |
(3S)-3-amino-4-(1H-imidazol-4-yl)-1-(phenylthio)butan-2-one dihydrochloride | - |
Brucella sp. | |
(3S)-3-amino-4-(1H-imidazol-4-yl)-1-(tolylthio)butan-2-one dihydrochloride | - |
Brucella sp. | |
additional information | synthesis and evaluation of alpha-O-arylketones and alpha-S-arylketones derived from histidine | Brucella sp. |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mn2+ | required | Brucella sp. |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Brucella sp. | - |
- |
- |
Purification (Comment) | Organism |
---|---|
recombinant His6-tagged enzyme from Escherichia coli strain BL21(DE3) by cobalt affinity chromatography | Brucella sp. |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-histidinol + 2 NAD+ + H2O | - |
Brucella sp. | L-histidine + 2 NADH + 3 H+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
HDH | - |
Brucella sp. |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
30 | - |
assay at | Brucella sp. |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
9.2 | - |
assay at | Brucella sp. |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | - |
Brucella sp. |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000024 | - |
pH 9.2, 30°C, recombinant His6-tagged enzyme | Brucella sp. | (3S)-3-amino-1-hydroxy-4-(1H-imidazol-4-yl)butan-2-one dihydrochloride | |
0.00011 | - |
pH 9.2, 30°C, recombinant His6-tagged enzyme | Brucella sp. | (3S)-3-amino-4-(1H-imidazol-4-yl)-1-(naphthalen-2-yloxy)butan-2-one dihydrochloride | |
0.00021 | - |
pH 9.2, 30°C, recombinant His6-tagged enzyme | Brucella sp. | (3S)-3-amino-4-(1H-imidazol-4-yl)-1-(p-tolyloxy)butan-2-one dihydrochloride | |
0.0016 | - |
pH 9.2, 30°C, recombinant His6-tagged enzyme | Brucella sp. | (3S)-3-amino-1-(4-bromophenoxy)-4-(1H-imidazol-4-yl)butan-2-one dihydrochloride | |
0.0021 | - |
pH 9.2, 30°C, recombinant His6-tagged enzyme | Brucella sp. | (3S)-3-amino-1-thio-4-(1H-imidazol-4-yl)butan-2-one dihydrochloride | |
0.0028 | - |
pH 9.2, 30°C, recombinant His6-tagged enzyme | Brucella sp. | (3S)-3-amino-1-(4-bromophenylthio)-4-(1H-imidazol-4-yl)butan-2-one dihydrochloride | |
0.0028 | - |
pH 9.2, 30°C, recombinant His6-tagged enzyme | Brucella sp. | (3S)-3-amino-1-(2,3,4,5,6-pentafluorophenyloxy)-4-(1H-imidazol-4-yl)butan-2-one dihydrochloride | |
0.0031 | - |
pH 9.2, 30°C, recombinant His6-tagged enzyme | Brucella sp. | (3S)-3-amino-1-(4-fluorophenylthio)-4-(1H-imidazol-4-yl)butan-2-one dihydrochloride | |
0.0033 | - |
pH 9.2, 30°C, recombinant His6-tagged enzyme | Brucella sp. | (3S)-3-amino-4-(1H-imidazol-4-yl)-1-(naphthalen-2-ylthio)butan-2-one dihydrochloride | |
0.0037 | - |
pH 9.2, 30°C, recombinant His6-tagged enzyme | Brucella sp. | (3S)-3-amino-4-(1H-imidazol-4-yl)-1-(phenyloxy)butan-2-one dihydrochloride | |
0.0047 | - |
pH 9.2, 30°C, recombinant His6-tagged enzyme | Brucella sp. | (3S)-3-amino-1-(4-fluorophenoxy)-4-(1H-imidazol-4-yl)butan-2-one dihydrochloride | |
0.0071 | - |
pH 9.2, 30°C, recombinant His6-tagged enzyme | Brucella sp. | (3S)-3-amino-4-(1H-imidazol-4-yl)-1-(phenylthio)butan-2-one dihydrochloride | |
0.0192 | - |
pH 9.2, 30°C, recombinant His6-tagged enzyme | Brucella sp. | (3S)-3-amino-1-(2,3,4,5,6-pentafluorophenylthio)-4-(1H-imidazol-4-yl)butan-2-one dihydrochloride | |
0.0395 | - |
pH 9.2, 30°C, recombinant His6-tagged enzyme | Brucella sp. | (3S)-3-amino-4-(1H-imidazol-4-yl)-1-(tolylthio)butan-2-one dihydrochloride |