Protein Variants | Comment | Organism |
---|---|---|
additional information | construction by Tn5 transposon mutagenesis of a knockout mutant of ugd, that is extremely sensitive to polymyxin B, presumably because of alterations in lipopolysaccharide structure and cell surface architecture in the mutant. The mutant is defective in swarming, expresses lower levels of virulence factor hemolysin, and has lower cell invasion ability. Complementation of the ugd or galU mutant with the full-length ugd gene leads to the restoration of wild-type phenotypic traits, phenotype, overview | Proteus mirabilis |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
UDP-glucose + 2 NAD+ + H2O | Proteus mirabilis | - |
UDP-glucuronic acid + 2 NADH + 2 H+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Proteus mirabilis | C3VI43 | gene ugd | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
UDP-glucose + 2 NAD+ + H2O | - |
Proteus mirabilis | UDP-glucuronic acid + 2 NADH + 2 H+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
UDP-glucose dehydrogenase | - |
Proteus mirabilis |
Ugd | - |
Proteus mirabilis |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | - |
Proteus mirabilis |
Organism | Comment | Expression |
---|---|---|
Proteus mirabilis | expression of Ugd is induced by polymyxin B through RppA, a putative response regulator of the bacterial two-component system | up |
General Information | Comment | Organism |
---|---|---|
additional information | mutation in either ugd leads to activation of RpoE, an extracytoplasmic function sigma factor that is activated by protein misfolding and alterations in cell surface structure in other bacteria. Activation of RpoE or RpoE overexpression causes inhibition of FlhDC and hemolysin expression | Proteus mirabilis |