Literature summary for 1.1.1.22 extracted from

Reen, R.K.; Jamwal, D.S.; Taneja, S.C.; Koul, J.L.; Dubey, R.K.; Wiebel, F.J.; Singh, J.
Impairment of UDP-glucose dehydrogenase and glucuronidation activities in liver and small intestine of rat and guinea pig in vitro by piperine (1993), Biochem. Pharmacol., 46, 229-238.

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Inhibitors

Inhibitors	Comment	Organism	Structure
piperine	stronger inhibition with intestinal cell enzyme than with rat liver enzyme	Cavia porcellus
piperine	non-competitive, reversible, non-pH-dependent, 90% inhibition at concentration 0.05 mM and 10% inhibition at concentration 0.01 mM	Rattus norvegicus

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.015	-	UDPglucose	pH 9.4	Rattus norvegicus
0.035	-	UDPglucose	pH 8.6	Rattus norvegicus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
microsome	-	Rattus norvegicus	-	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
UDPglucose + NAD+ + H2O	Cavia porcellus	-	UDPglucuronate + NADH	-	?
UDPglucose + NAD+ + H2O	Rattus norvegicus	-	UDPglucuronate + NADH	-	?

Organism

Organism	UniProt	Comment	Textmining
Cavia porcellus	-	-	-
Rattus norvegicus	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
partial	Rattus norvegicus

Source Tissue

Source Tissue	Comment	Organism	Textmining
liver	-	Cavia porcellus	-
liver	-	Rattus norvegicus	-
small intestine	-	Cavia porcellus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3-OH-benzopyrene + NAD+	-	Rattus norvegicus	?	-	?
UDP-glucose + 2 NAD+ + H2O	-	Cavia porcellus	UDP-glucuronate + 2 NADH + 2 H+	-	?
UDP-glucose + 2 NAD+ + H2O	-	Rattus norvegicus	UDP-glucuronate + 2 NADH + 2 H+	-	?
UDPglucose + NAD+ + H2O	-	Cavia porcellus	UDPglucuronate + NADH	-	?
UDPglucose + NAD+ + H2O	-	Rattus norvegicus	UDPglucuronate + NADH	-	?

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
8.6	-	two pH optima, pH 8.6 and pH 9.4	Rattus norvegicus
9.4	-	two pH optima, pH 8.6 and pH 9.4	Rattus norvegicus

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Release 2023.1 (January 2023)