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Literature summary for 1.1.1.213 extracted from

  • Bauman, D.R.; Steckelbroeck, S.; Williams, M.V.; Peehl, D.M.; Penning, T.M.
    Identification of the major oxidative 3alpha-hydroxysteroid dehydrogenase in human prostate that converts 5alpha-androstane-3alpha,17beta-diol to 5alpha-dihydrotestosterone: a potential therapeutic target for androgen-dependent disease (2006), Mol. Endocrinol., 20, 444-458.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
transient functional expression in PC3 and COS-1 cells, trans-activation of the enzyme using a CAT reporter gene assay, overview Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5alpha-dihydrotestosterone + NADPH Homo sapiens androgen-inactivating enzyme 5alpha-androstane-3alpha,17beta-diol + NADP+
-
r
additional information Homo sapiens the RODH like 3alpha/17beta-HSD, EC 1.1.1.239, regulates the transactivation of AKR1C2, overview ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens P52895 gene AKR1C2 or DDH2
-

Source Tissue

Source Tissue Comment Organism Textmining
prostate gland in primary prostate stromal cells, co-localization with RODH like 3alpha/17beta-HSD, EC 1.1.1.239 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5alpha-dihydrotestosterone + NADPH androgen-inactivating enzyme Homo sapiens 5alpha-androstane-3alpha,17beta-diol + NADP+
-
r
5alpha-dihydrotestosterone + NADPH i.e. DHT, the enzyme prefers the reductive reaction Homo sapiens 5alpha-androstane-3alpha,17beta-diol + NADP+
-
r
additional information the RODH like 3alpha/17beta-HSD, EC 1.1.1.239, regulates the transactivation of AKR1C2, overview Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
3alpha-HSD
-
Homo sapiens
3alpha-hydroxysteroid dehydrogenase
-
Homo sapiens
AKR1C2
-
Homo sapiens
type 3 3alpha-HSD
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NADP+
-
Homo sapiens
NADPH
-
Homo sapiens