Cloned (Comment) | Organism |
---|---|
transient functional expression in PC3 and COS-1 cells, trans-activation of the enzyme using a CAT reporter gene assay, overview | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Homo sapiens | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
5alpha-dihydrotestosterone + NADPH | Homo sapiens | androgen-inactivating enzyme | 5alpha-androstane-3alpha,17beta-diol + NADP+ | - |
r | |
additional information | Homo sapiens | the RODH like 3alpha/17beta-HSD, EC 1.1.1.239, regulates the transactivation of AKR1C2, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P52895 | gene AKR1C2 or DDH2 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
prostate gland | in primary prostate stromal cells, co-localization with RODH like 3alpha/17beta-HSD, EC 1.1.1.239 | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
5alpha-dihydrotestosterone + NADPH | androgen-inactivating enzyme | Homo sapiens | 5alpha-androstane-3alpha,17beta-diol + NADP+ | - |
r | |
5alpha-dihydrotestosterone + NADPH | i.e. DHT, the enzyme prefers the reductive reaction | Homo sapiens | 5alpha-androstane-3alpha,17beta-diol + NADP+ | - |
r | |
additional information | the RODH like 3alpha/17beta-HSD, EC 1.1.1.239, regulates the transactivation of AKR1C2, overview | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
3alpha-HSD | - |
Homo sapiens |
3alpha-hydroxysteroid dehydrogenase | - |
Homo sapiens |
AKR1C2 | - |
Homo sapiens |
type 3 3alpha-HSD | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADP+ | - |
Homo sapiens | |
NADPH | - |
Homo sapiens |