KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.505 | - |
17beta-hydroxy-5alpha-androstan-3-one | NAD(H), prostate | Rattus norvegicus | |
0.614 | - |
17beta-hydroxy-5alpha-androstan-3-one | NADP(H), prostate | Rattus norvegicus | |
0.645 | - |
17beta-hydroxy-5alpha-androstan-3-one | NADP(H), epididymis | Rattus norvegicus | |
0.726 | - |
17beta-hydroxy-5alpha-androstan-3-one | NAD(H), epididymis | Rattus norvegicus | |
0.781 | - |
5alpha-androstane-3alpha,17beta-diol | NAD(H), prostate | Rattus norvegicus | |
1.09 | - |
5alpha-androstane-3alpha,17beta-diol | NADP(H), prostate | Rattus norvegicus | |
3.042 | - |
5alpha-androstane-3alpha,17beta-diol | NAD(H), epididymis | Rattus norvegicus | |
7.331 | - |
5alpha-androstane-3alpha,17beta-diol | NADP(H), epididymis | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | - |
Rattus norvegicus | 5737 | - |
nucleus | - |
Rattus norvegicus | 5634 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
Wistar, 7-13 weeks old | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
epididymis | - |
Rattus norvegicus | - |
prostate gland | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
17beta-hydroxy-5alpha-androstan-3-one + NAD(P)H | the rate of dihydrotestosterone reduction over back-conversion is 2.4 and 5.9 for prostate and epididymis, respectively | Rattus norvegicus | 5alpha-androstane-3alpha,17beta-diol + NAD(P)+ | - |
r |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | higher activity | Rattus norvegicus | |
NADH | higher activity | Rattus norvegicus | |
NADP+ | lower activity | Rattus norvegicus | |
NADPH | lower activity | Rattus norvegicus |