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Literature summary for 1.1.1.21 extracted from

  • Iqbal, Z.; Hameed, S.; Ali, S.; Tehseen, Y.; Shahid, M.; Iqbal, J.
    Synthesis, characterization, hypoglycemic and aldose reductase inhibition activity of arylsulfonylspiro[fluorene-9,5-imidazolidine]-2,4-diones (2015), Eur. J. Med. Chem., 98, 127-138.
    View publication on PubMed
Search for more literature for 1.1.1.21

Inhibitors

Inhibitors Comment Organism Structure
1'-(4-bromophenylsulfonyl)spiro[fluorene-9,5'-imidazolidine]-2',4'-dione
-
 Bos taurus
1'-(4-chlorophenylsulfonyl)spiro[fluorene-9,5'-imidazolidine]-2',4'-dione
-
 Bos taurus
1'-(4-methoxyphenylsulfonyl)spiro[fluorene-9,5'-imidazolidine]-2',4'-dione
-
 Bos taurus
1'-(4-methylphenylsulfonyl)spiro[fluorene-9,5'-imidazolidine]-2',4'-dione
-
 Bos taurus
1'-(4-nitrophenylsulfonyl)spiro[fluorene-9,5'-imidazolidine]-2',4'-dione
-
 Bos taurus
1'-(9,10-dioxo-9,10-dihydroanthracen-2-ylsulfonyl)spiro[fluorene-9,5'-imidazolidine]-2',4'-dione
-
 Bos taurus
1'-(naphthalen-2-ylsulfonyl)spiro[fluorene-9,5'-imidazolidine]-2',4'-dione
-
 Bos taurus
3'-(4-bromophenylsulfonyl)spiro[fluorene-9,5'-imidazolidine]-2',4'-dione
-
 Bos taurus
3'-(4-chlorophenylsulfonyl)spiro[fluorene-9,5'-imidazolidine]-2',4'-dione
-
 Bos taurus
3'-(4-methoxyphenylsulfonyl)spiro[fluorene-9,5'-imidazolidine]-2',4'-dione
-
 Bos taurus
3'-(4-methylphenylsulfonyl)spiro[fluorene-9,50-imidazolidine]-2',4'-dione
-
 Bos taurus
3'-(4-nitrophenylsulfonyl)spiro[fluorene-9,5'-imidazolidine]-2',4'-dione
-
 Bos taurus
3'-(9,10-dioxo-9,10-dihydroanthracen-2-ylsulfonyl)spiro[fluorene-9,5'-imidazolidine]-2',4'-dione
-
 Bos taurus
3'-(naphthalen-2-ylsulfonyl)spiro[fluorene-9,5'-imidazolidine]-2',4'-dione
-
 Bos taurus
additional information synthesis, characterization, hypoglycemic and aldose reductase inhibition activity of arylsulfonylspiro[fluorene-9,5-imidazolidine]-2,4-diones, analysis of the Kador-Sharpless model for minimal pharmacophoric requirements for an aldose reductase inhibitor, and superposition of target molecules on a hypoglycemic pharmacophoric model and a aldose reductase pharmacophoric model, overview. Molecular dynamics simulations and inhibitor binding model. Effects of the compounds on diabetic BALB/c mice Bos taurus
Valproic acid
-
 Bos taurus

Organism

Organism UniProt Comment Textmining
Bos taurus P16116
-
-

Purification (Commentary)

Purification (Comment) Organism
native isozymes partially by ammonium sulfate fractionation and dialysis Bos taurus

Source Tissue

Source Tissue Comment Organism Textmining
kidney calf Bos taurus
-
lens calf Bos taurus
-

Synonyms

Synonyms Comment Organism
AKR1B1
-
 Bos taurus
ALR2
-
 Bos taurus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
additional information
-
 inhibition kinetics and thermodynamics, overview Bos taurus additional information