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Literature summary for 1.1.1.21 extracted from

  • Stefek, M.; Tsantili-Kakoulidou, A.; Milackova, I.; Juskova, M.; Snirc, V.; Triantos, N.
    (2-Benzyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indol-8-yl)-acetic acid: an aldose reductase inhibitor and antioxidant of zwitterionic nature (2011), Bioorg. Med. Chem., 19, 7181-7185.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
(2-benzyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indol-8-yl)-acetic acid an aldose reductase inhibitor and antioxidant of zwitterionic nature Rattus norvegicus
stobadine i.e. (-)-cis-2,8-dimethyl-2,3,4,4a,5,9b-hexahydro-1H-pyrido[4,3,-b]indole Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-
Rattus norvegicus Wistar
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
erythrocyte
-
Rattus norvegicus
-

Synonyms

Synonyms Comment Organism
aldose reductase
-
Rattus norvegicus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0182
-
pH and temperature not specified in the publication Rattus norvegicus (2-benzyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indol-8-yl)-acetic acid

General Information

General Information Comment Organism
physiological function the enzyme is involved in sorbitol accumulation in red blood cells after peroxide, e.g. 2,2'-azobis(2-amidinopropane) hydrochloride and tert-butyl hydroperoxide, induced hemolysis, overview Rattus norvegicus