Literature summary for 1.1.1.21 extracted from

Fu, J.; Tay, S.S.; Ling, E.A.; Dheen, S.T.
Aldose reductase is implicated in high glucose-induced oxidative stress in mouse embryonic neural stem cells (2007), J. Neurochem., 103, 1654-1665.

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Application

Application	Comment	Organism
medicine	inhibition of enzyme in neural stem cells exposed to high glucose concentration results in decrease of oxidative stress, restoration of cell viability and proliferation, and reduction of apoptotic cell death. Inhibition attenuates the down-regulation of glucose transporter 1 expression	Mus musculus

Inhibitors

Inhibitors	Comment	Organism	Structure
fidarestat	inhibition of enzyme in neural stem cells exposed to high glucose concentration results in decrease of oxidative stress, restoration of cell viability and proliferation, and reduction of apoptotic cell death. Inhibition attenuates the down-regulation of glucose transporter 1 expression	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
embryo	-	Mus musculus	-
neural stem cell	-	Mus musculus	-

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Release 2023.1 (January 2023)