Literature summary for 1.1.1.21 extracted from

Ramana, K.V.; Friedrich, B.; Bhatnagar, A.; Srivastava, S.K.
Aldose reductase mediates cytotoxic signals of hyperglycemia and TNF-alpha in human lens epithelial cells (2003), FASEB J., 17, 315-317.

Search for more literature for 1.1.1.21

Application

Application	Comment	Organism
medicine	inhibition of enzyme by tolrestat or sorbinil prevents apotosis and activation of calpase-3, attenuation of TNF-alpha and hyperglykemia-induced activation of protein kinase C, but does not prevent the activation of transkription factor NK-kappaB and protein kinase C by phorbol ester, enzyme is an obligatory mediator of the apoptotic events upstream of protein kinase C	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
sorbinil	inhibition of enzyme, preventing apotosis and activation of caspase-3, attenuation of TNF-alpha and hyperglykemia-induced activation of protein kinase C	Homo sapiens
Tolrestat	inhibition of enzyme, preventing apotosis and activation of caspase-3, attenuation of TNF-alpha and hyperglykemia-induced activation of protein kinase C	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
HLE B-3 cell	lens epithelial cell line	Homo sapiens	-

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Release 2023.1 (January 2023)