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Literature summary for 1.1.1.21 extracted from

  • Halder, A.B.; Crabbe, M.J.C.
    Bovine lens aldehyde reductase (aldose reductase) (1984), Biochem. J., 219, 33-39.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
2-[5-fluoro-2-methyl-1-p-(methylsulphinyl)benzylidine]indene-3-acetic acid non-competitive Bos taurus
disodium 4,6-dioxo-10-propyl-4H,6H-pyranol[3,2-g-]-quinoline-2,8-dicarboxylate non-competitive Bos taurus
glyceraldehyde substrate inhibition Bos taurus
malondialdehyde at concentration above 0.8 mM substrate inhibition Bos taurus
NADP+ competitve to NADPH Bos taurus
p-nitrobenzaldehyde at concentration above 2 mM substrate inhibition Bos taurus
sorbitol competitive inhibition with NADP+ and glucose Bos taurus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
8.2
-
NADPH
-
Bos taurus
21.8
-
glucose
-
Bos taurus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
32000
-
gel filtration Bos taurus
40000
-
1 * 40000, about, SDS-PAGE Bos taurus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
aldose + NAD(P)H Bos taurus
-
alditol + NAD(P)+
-
r

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Bos taurus

Source Tissue

Source Tissue Comment Organism Textmining
lens
-
Bos taurus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.2
-
purified enzyme Bos taurus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
alditol + NAD(P)+
-
Bos taurus aldose + NAD(P)H
-
r
aldose + NAD(P)H
-
Bos taurus alditol + NAD(P)+
-
r
D-fructose + NAD(P)H + H+
-
Bos taurus D-arabino-hexitol + NAD(P)+
-
r
D-glucose + NAD(P)H
-
Bos taurus sorbitol + NAD(P)+
-
?
D-xylose + NAD(P)H
-
Bos taurus xylitol + NAD(P)+
-
r
DL-glyceraldehyde + NAD(P)H
-
Bos taurus glycerol + NAD(P)+
-
r
xylitol + NAD(P)+
-
Bos taurus D-xylose + NAD(P)H + H+
-
r

Subunits

Subunits Comment Organism
monomer 1 * 40000, about, SDS-PAGE Bos taurus

pH Range

pH Minimum pH Maximum Comment Organism
additional information
-
inactive below pH 5.9 Bos taurus

Cofactor

Cofactor Comment Organism Structure
NADH
-
Bos taurus
NADP+
-
Bos taurus