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Literature summary for 1.1.1.21 extracted from

  • Tanimoto, T.; Ohta, M.; Tanaka, A.; Ikemoto, I.; Machida, T.
    Purification and characterization of human testis aldose and aldehyde reductase (1991), Int. J. Biochem., 23, 421-428.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
(NH4)2SO4 at 0.3 M more than 3fold activity Homo sapiens
(NH4)2SO4 0.1 M Homo sapiens
Na2SO4 at 0.3 M 3fold activity Homo sapiens
pyridoxal 5'-phosphate 2,5fold activity at 0,5 mM Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
(E,E)-5[2-methyl-3-phenyl-2-propenylidene-4-oxo-2-thioxo-3-thiazolidine]acetic acid
-
Homo sapiens
(S)-6-fluorospiro[chroman-4,5'-imidazolidine]-2',4'-dione
-
Homo sapiens
N-[[6-methoxy-5(trifluoromethyl)-1-naphthalenyl]thioxomethyl]-N-methylglycine
-
Homo sapiens
ponalrestat
-
Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0032
-
NADPH
-
Homo sapiens
0.025
-
DL-glyceraldehyde
-
Homo sapiens
0.25
-
NADH
-
Homo sapiens
5.05
-
D-glucuronate
-
Homo sapiens
6.2
-
D-xylose
-
Homo sapiens
49.3
-
D-galactose
-
Homo sapiens
57.3
-
D-glucose
-
Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
36000
-
1 * 36000, SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
aldose + NAD(P)H Homo sapiens
-
alditol + NAD(P)+
-
r

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
testis
-
Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.32
-
purified enzyme, NADPH Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
alditol + NAD(P)+
-
Homo sapiens aldose + NAD(P)H
-
r
aldose + NAD(P)H
-
Homo sapiens alditol + NAD(P)+
-
r
aldose + NAD(P)H wide specificity Homo sapiens alditol + NAD(P)+
-
r
D-galactose + NAD(P)H
-
Homo sapiens dulcitol + NAD(P)+
-
r
D-glucose + NAD(P)H
-
Homo sapiens sorbitol + NAD(P)+
-
r
D-glucuronate + NAD(P)H
-
Homo sapiens ?
-
r
D-xylose + NAD(P)H
-
Homo sapiens xylitol + NAD(P)+
-
r
DL-glyceraldehyde + NAD(P)H
-
Homo sapiens glycerol + NAD(P)+
-
r
xylitol + NAD(P)+
-
Homo sapiens D-xylose + NAD(P)H + H+
-
r

Subunits

Subunits Comment Organism
monomer 1 * 36000, SDS-PAGE Homo sapiens

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.183
-
D-glucose
-
Homo sapiens
0.233
-
D-galactose
-
Homo sapiens
0.431
-
DL-glyceraldehyde
-
Homo sapiens
1.7
-
D-xylose
-
Homo sapiens
2.3
-
D-glucuronate
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NADH
-
Homo sapiens
NADPH
-
Homo sapiens