KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0113 | - |
NADPH | - |
Hyoscyamus niger | |
0.0415 | - |
NADP+ | - |
Hyoscyamus niger | |
0.058 | - |
NADPH | - |
Datura stramonium | |
0.105 | - |
NADP+ | - |
Datura stramonium | |
0.775 | - |
tropinone | pH 5.9 | Datura stramonium | |
1.01 | - |
tropinone | pH 5.9 | Hyoscyamus niger | |
1.3 | - |
tropinone | pH 6.4 | Datura stramonium |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
tropinone + NADPH + H+ | Datura stramonium | tropine is the precursor of the tropane alkaloids hyoscyamine and scopolamine | tropine + NADP+ | - |
r | |
tropinone + NADPH + H+ | Atropa belladonna | tropine is the precursor of the tropane alkaloids hyoscyamine and scopolamine | tropine + NADP+ | - |
? | |
tropinone + NADPH + H+ | Duboisia myoporoides | tropine is the precursor of the tropane alkaloids hyoscyamine and scopolamine | tropine + NADP+ | - |
? | |
tropinone + NADPH + H+ | Duboisia leichhardtii | tropine is the precursor of the tropane alkaloids hyoscyamine and scopolamine | tropine + NADP+ | - |
? | |
tropinone + NADPH + H+ | Hyoscyamus niger | tropine is the precursor of the tropane alkaloids hyoscyamine and scopolamine | tropine + NADP+ | - |
r | |
tropinone + NADPH + H+ | Hyoscyamus muticus | tropine is the precursor of the tropane alkaloids hyoscyamine and scopolamine | tropine + NADP+ | - |
? | |
tropinone + NADPH + H+ | Scopolia atropoides | tropine is the precursor of the tropane alkaloids hyoscyamine and scopolamine | tropine + NADP+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Atropa belladonna | - |
- |
- |
Datura stramonium | - |
- |
- |
Duboisia leichhardtii | - |
- |
- |
Duboisia myoporoides | - |
- |
- |
Hyoscyamus muticus | - |
- |
- |
Hyoscyamus niger | - |
- |
- |
Scopolia atropoides | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
3-methyl-cyclohexanone + NADPH | 85% of the reaction velocity with tropinone | Hyoscyamus niger | 3-methylcyclohexanol + NADP+ | - |
? | |
4-ethylcyclohexanone + NADPH | 107% of the reaction velocity with tropinone | Hyoscyamus niger | 4-ethylcyclohexanol + NADP+ | - |
? | |
4-ethylcyclohexanone + NADPH | 41% of the reaction velocity with tropinone | Datura stramonium | 4-ethylcyclohexanol + NADP+ | - |
? | |
4-tetrahydro-thiopyranone + NADPH | 83% of the reaction velocity with tropinone | Datura stramonium | ? | - |
? | |
8-thiabicyclo[3.2.1]octan-3-one + NADPH | 35% of the reaction velocity with tropinone | Datura stramonium | ? | - |
? | |
8-thiabicyclo[3.2.1]octan-3-one + NADPH | 40% of the reaction velocity with tropinone | Hyoscyamus niger | ? | - |
? | |
additional information | no activity with 3-methyl-cyclohexanone | Datura stramonium | ? | - |
? | |
additional information | no activity with N-propyl-4-pieridinone and 4-tetrahydro-thiopyranone | Hyoscyamus niger | ? | - |
? | |
N-methyl-4-piperidinone + NADPH | 180% of the reaction velocity with tropinone | Datura stramonium | N-methyl-1-piperidinol + NADP+ | - |
? | |
N-methyl-4-piperidinone + NADPH + H+ | 13% of the reaction velocity with tropinone | Hyoscyamus niger | N-methyl-1-piperidinol + NADP+ | - |
? | |
N-propyl-4-piperidinone + NADPH | 78% of the reaction velocity with tropinone | Datura stramonium | N-propylpiperidinol + NADP+ | - |
? | |
quinuclidinone + NADPH | 136% of the reaction velocity with tropinone | Hyoscyamus niger | ? | - |
? | |
quinuclidinone + NADPH | 80% of the reaction velocity with tropinone | Datura stramonium | ? | - |
? | |
tropinone + NADPH + H+ | - |
Datura stramonium | tropine + NADP+ | - |
r | |
tropinone + NADPH + H+ | - |
Atropa belladonna | tropine + NADP+ | - |
? | |
tropinone + NADPH + H+ | - |
Duboisia myoporoides | tropine + NADP+ | - |
? | |
tropinone + NADPH + H+ | - |
Duboisia leichhardtii | tropine + NADP+ | - |
? | |
tropinone + NADPH + H+ | - |
Hyoscyamus niger | tropine + NADP+ | - |
r | |
tropinone + NADPH + H+ | - |
Hyoscyamus muticus | tropine + NADP+ | - |
? | |
tropinone + NADPH + H+ | - |
Scopolia atropoides | tropine + NADP+ | - |
? | |
tropinone + NADPH + H+ | tropine is the precursor of the tropane alkaloids hyoscyamine and scopolamine | Datura stramonium | tropine + NADP+ | - |
r | |
tropinone + NADPH + H+ | tropine is the precursor of the tropane alkaloids hyoscyamine and scopolamine | Atropa belladonna | tropine + NADP+ | - |
? | |
tropinone + NADPH + H+ | tropine is the precursor of the tropane alkaloids hyoscyamine and scopolamine | Duboisia myoporoides | tropine + NADP+ | - |
? | |
tropinone + NADPH + H+ | tropine is the precursor of the tropane alkaloids hyoscyamine and scopolamine | Duboisia leichhardtii | tropine + NADP+ | - |
? | |
tropinone + NADPH + H+ | tropine is the precursor of the tropane alkaloids hyoscyamine and scopolamine | Hyoscyamus niger | tropine + NADP+ | - |
r | |
tropinone + NADPH + H+ | tropine is the precursor of the tropane alkaloids hyoscyamine and scopolamine | Hyoscyamus muticus | tropine + NADP+ | - |
? | |
tropinone + NADPH + H+ | tropine is the precursor of the tropane alkaloids hyoscyamine and scopolamine | Scopolia atropoides | tropine + NADP+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
TRI | - |
Datura stramonium |
TRI | - |
Atropa belladonna |
TRI | - |
Duboisia myoporoides |
TRI | - |
Duboisia leichhardtii |
TRI | - |
Hyoscyamus niger |
TRI | - |
Hyoscyamus muticus |
TRI | - |
Scopolia atropoides |
tropinone reductase | - |
Datura stramonium |
tropinone reductase | - |
Atropa belladonna |
tropinone reductase | - |
Duboisia myoporoides |
tropinone reductase | - |
Duboisia leichhardtii |
tropinone reductase | - |
Hyoscyamus niger |
tropinone reductase | - |
Hyoscyamus muticus |
tropinone reductase | - |
Scopolia atropoides |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
25.6 | - |
tropinone | pH 7.0 | Datura stramonium |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
6.1 | - |
reduction reaction | Hyoscyamus niger |
6.4 | - |
reduction reaction | Datura stramonium |
7.6 | - |
oxidation reaction | Hyoscyamus niger |
9.9 | - |
oxidation reaction | Datura stramonium |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | - |
Datura stramonium | |
NADPH | - |
Atropa belladonna | |
NADPH | - |
Duboisia myoporoides | |
NADPH | - |
Duboisia leichhardtii | |
NADPH | - |
Hyoscyamus niger | |
NADPH | - |
Hyoscyamus muticus | |
NADPH | - |
Scopolia atropoides |