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Literature summary for 1.1.1.206 extracted from

  • Draeger, B.
    Tropinone reductases, enzymes at the branch point of tropane alkaloid metabolism (2006), Phytochemistry, 67, 327-337.
    View publication on PubMed

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0113
-
NADPH
-
Hyoscyamus niger
0.0415
-
NADP+
-
Hyoscyamus niger
0.058
-
NADPH
-
Datura stramonium
0.105
-
NADP+
-
Datura stramonium
0.775
-
tropinone pH 5.9 Datura stramonium
1.01
-
tropinone pH 5.9 Hyoscyamus niger
1.3
-
tropinone pH 6.4 Datura stramonium

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
tropinone + NADPH + H+ Datura stramonium tropine is the precursor of the tropane alkaloids hyoscyamine and scopolamine tropine + NADP+
-
r
tropinone + NADPH + H+ Atropa belladonna tropine is the precursor of the tropane alkaloids hyoscyamine and scopolamine tropine + NADP+
-
?
tropinone + NADPH + H+ Duboisia myoporoides tropine is the precursor of the tropane alkaloids hyoscyamine and scopolamine tropine + NADP+
-
?
tropinone + NADPH + H+ Duboisia leichhardtii tropine is the precursor of the tropane alkaloids hyoscyamine and scopolamine tropine + NADP+
-
?
tropinone + NADPH + H+ Hyoscyamus niger tropine is the precursor of the tropane alkaloids hyoscyamine and scopolamine tropine + NADP+
-
r
tropinone + NADPH + H+ Hyoscyamus muticus tropine is the precursor of the tropane alkaloids hyoscyamine and scopolamine tropine + NADP+
-
?
tropinone + NADPH + H+ Scopolia atropoides tropine is the precursor of the tropane alkaloids hyoscyamine and scopolamine tropine + NADP+
-
?

Organism

Organism UniProt Comment Textmining
Atropa belladonna
-
-
-
Datura stramonium
-
-
-
Duboisia leichhardtii
-
-
-
Duboisia myoporoides
-
-
-
Hyoscyamus muticus
-
-
-
Hyoscyamus niger
-
-
-
Scopolia atropoides
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3-methyl-cyclohexanone + NADPH 85% of the reaction velocity with tropinone Hyoscyamus niger 3-methylcyclohexanol + NADP+
-
?
4-ethylcyclohexanone + NADPH 107% of the reaction velocity with tropinone Hyoscyamus niger 4-ethylcyclohexanol + NADP+
-
?
4-ethylcyclohexanone + NADPH 41% of the reaction velocity with tropinone Datura stramonium 4-ethylcyclohexanol + NADP+
-
?
4-tetrahydro-thiopyranone + NADPH 83% of the reaction velocity with tropinone Datura stramonium ?
-
?
8-thiabicyclo[3.2.1]octan-3-one + NADPH 35% of the reaction velocity with tropinone Datura stramonium ?
-
?
8-thiabicyclo[3.2.1]octan-3-one + NADPH 40% of the reaction velocity with tropinone Hyoscyamus niger ?
-
?
additional information no activity with 3-methyl-cyclohexanone Datura stramonium ?
-
?
additional information no activity with N-propyl-4-pieridinone and 4-tetrahydro-thiopyranone Hyoscyamus niger ?
-
?
N-methyl-4-piperidinone + NADPH 180% of the reaction velocity with tropinone Datura stramonium N-methyl-1-piperidinol + NADP+
-
?
N-methyl-4-piperidinone + NADPH + H+ 13% of the reaction velocity with tropinone Hyoscyamus niger N-methyl-1-piperidinol + NADP+
-
?
N-propyl-4-piperidinone + NADPH 78% of the reaction velocity with tropinone Datura stramonium N-propylpiperidinol + NADP+
-
?
quinuclidinone + NADPH 136% of the reaction velocity with tropinone Hyoscyamus niger ?
-
?
quinuclidinone + NADPH 80% of the reaction velocity with tropinone Datura stramonium ?
-
?
tropinone + NADPH + H+
-
Datura stramonium tropine + NADP+
-
r
tropinone + NADPH + H+
-
Atropa belladonna tropine + NADP+
-
?
tropinone + NADPH + H+
-
Duboisia myoporoides tropine + NADP+
-
?
tropinone + NADPH + H+
-
Duboisia leichhardtii tropine + NADP+
-
?
tropinone + NADPH + H+
-
Hyoscyamus niger tropine + NADP+
-
r
tropinone + NADPH + H+
-
Hyoscyamus muticus tropine + NADP+
-
?
tropinone + NADPH + H+
-
Scopolia atropoides tropine + NADP+
-
?
tropinone + NADPH + H+ tropine is the precursor of the tropane alkaloids hyoscyamine and scopolamine Datura stramonium tropine + NADP+
-
r
tropinone + NADPH + H+ tropine is the precursor of the tropane alkaloids hyoscyamine and scopolamine Atropa belladonna tropine + NADP+
-
?
tropinone + NADPH + H+ tropine is the precursor of the tropane alkaloids hyoscyamine and scopolamine Duboisia myoporoides tropine + NADP+
-
?
tropinone + NADPH + H+ tropine is the precursor of the tropane alkaloids hyoscyamine and scopolamine Duboisia leichhardtii tropine + NADP+
-
?
tropinone + NADPH + H+ tropine is the precursor of the tropane alkaloids hyoscyamine and scopolamine Hyoscyamus niger tropine + NADP+
-
r
tropinone + NADPH + H+ tropine is the precursor of the tropane alkaloids hyoscyamine and scopolamine Hyoscyamus muticus tropine + NADP+
-
?
tropinone + NADPH + H+ tropine is the precursor of the tropane alkaloids hyoscyamine and scopolamine Scopolia atropoides tropine + NADP+
-
?

Synonyms

Synonyms Comment Organism
TRI
-
Datura stramonium
TRI
-
Atropa belladonna
TRI
-
Duboisia myoporoides
TRI
-
Duboisia leichhardtii
TRI
-
Hyoscyamus niger
TRI
-
Hyoscyamus muticus
TRI
-
Scopolia atropoides
tropinone reductase
-
Datura stramonium
tropinone reductase
-
Atropa belladonna
tropinone reductase
-
Duboisia myoporoides
tropinone reductase
-
Duboisia leichhardtii
tropinone reductase
-
Hyoscyamus niger
tropinone reductase
-
Hyoscyamus muticus
tropinone reductase
-
Scopolia atropoides

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
25.6
-
tropinone pH 7.0 Datura stramonium

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.1
-
reduction reaction Hyoscyamus niger
6.4
-
reduction reaction Datura stramonium
7.6
-
oxidation reaction Hyoscyamus niger
9.9
-
oxidation reaction Datura stramonium

Cofactor

Cofactor Comment Organism Structure
NADPH
-
Datura stramonium
NADPH
-
Atropa belladonna
NADPH
-
Duboisia myoporoides
NADPH
-
Duboisia leichhardtii
NADPH
-
Hyoscyamus niger
NADPH
-
Hyoscyamus muticus
NADPH
-
Scopolia atropoides