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Literature summary for 1.1.1.205 extracted from

  • Glander, P.; Sombogaard, F.; Budde, K.; van Gelder, T.; Hambach, P.; Liefeldt, L.; Lorkowski, C.; Mai, M.; Neumayer, H.H.; Vulto, A.G.; Mathot, R.A.
    Improved assay for the nonradioactive determination of inosine 5-monophosphate dehydrogenase activity in peripheral blood mononuclear cells (2009), Ther. Drug Monit., 31, 351-359.
    View publication on PubMed
Search for more literature for 1.1.1.205

Application

Application Comment Organism
medicine modified method for the measurement of IMPDH activity, that is less labor-intensive, more robust in general, and capable of yielding a better reproducibility, which can be used reliably in multicenter trials and in longitudinal studies to evaluate the additional value of any pharmacodynamic monitoring among a diversity of patients treated with mycophenolic acid Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
additional information IMPDH activity decreases more than 10% with increasing contamination by erythrocytes due to increasing AMP and protein content. Storage of lithium heparin blood samples at room temperature for 24 hours before peripheral blood mononuclear cell isolation does not lead to any significant changes in the IMPDH activity, when the activity is normalized to the AMP concentration Homo sapiens
mycophenolate mofetil
-
 Homo sapiens
Mycophenolic acid
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
peripheral blood mononuclear cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
inosine 5'-phosphate + NAD+ + H2O
-
 Homo sapiens xanthosine 5'-phosphate + NADH
-
 ?

Synonyms

Synonyms Comment Organism
IMPDH
-
 Homo sapiens
inosine 5'-monophosphate dehydrogenase
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NAD+
-
 Homo sapiens