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Literature summary for 1.1.1.205 extracted from

  • Brandhorst, G.; Marquet, P.; Shaw, L.M.; Liebisch, G.; Schmitz, G.; Coffing, M.J.; Domke, I.; Streit, F.; Luthe, H.; Oellerich, M.
    Multicenter evaluation of a new inosine monophosphate dehydrogenase inhibition assay for quantification of total mycophenolic acid in plasma (2008), Ther. Drug Monit., 30, 428-433.
    View publication on PubMed

Application

Application Comment Organism
drug development Roche total mycophenolic acid assay (a new inosine monophosphate dehydrogenase inhibition assay) is a promising alternative for mycophenolic acid quantification where chromatographic methods are not available Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
Mycophenolic acid new enzymatic mycophenolic acid assay, cross-reactivity by mycophenolic acid-acyl-glucuronide is less than 5%, thus interference is expected to be clinically irrelevant Homo sapiens
mycophenolic acid-acyl-glucuronide cross-reactivity by mycophenolic acid is less than 5%, thus interference is expected to be clinically irrelevant Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
plasma
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
inosine 5'-phosphate + NAD+ + H2O
-
Homo sapiens xanthosine 5'-phosphate + NADH
-
?

Synonyms

Synonyms Comment Organism
inosine monophosphate dehydrogenase
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Homo sapiens