Activating Compound | Comment | Organism | Structure |
---|---|---|---|
mycophenolate mofetil | median IMPDH activity in erythrocytes is 1.73times higher in mycophenolate mofetil positive than in mycophenolate mofetil negative kidney transplant recipients. Predose IMPDH activity in erythrocytes is induced slowly by mycophenolate mofetil therapy and is dependent on mycophenolic acid, phenolic and acyl glucuronides in stable kidney transplant recipients | Homo sapiens |
Application | Comment | Organism |
---|---|---|
medicine | IMPDH activity in erythrocytes may be useful indicator of short-term immunosuppression and long-term exposure of the immunosuppressant mycophenolic acid | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Mycophenolic acid | IMPDH activity in erythrocytes is inhibited at the peak plasma concentration of mycophenolic acid in initial kidney transplant recipients. Reduction does not coincide with the peak of the plasma concentration of phenolic and acyl glucuronides of mycophenolic acid | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
erythrocyte | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
IMPDH | - |
Homo sapiens |
inosine monophosphate dehydrogenase | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | increase in IMPDH activity in erythrocytes after kidney transplantation | up |