Literature summary for 1.1.1.205 extracted from

Dobie, F.; Berg, A.; Boitz, J.M.; Jardim, A.
Kinetic characterization of inosine monophosphate dehydrogenase of Leishmania donovani (2007), Mol. Biochem. Parasitol., 152, 11-21.

Search for more literature for 1.1.1.205

Cloned(Commentary)

Cloned (Comment)	Organism
expression in Escherichia coli	Leishmania donovani

Inhibitors

Inhibitors	Comment	Organism	Structure
GMP	-	Leishmania donovani
Mycophenolic acid	-	Leishmania donovani
XMP	-	Leishmania donovani

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.033	-	inosine 5'-phosphate	pH 7.5, 25°C	Leishmania donovani
0.39	-	NAD+	pH 7.5, 25°C	Leishmania donovani

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
glycosome	-	Leishmania donovani	20015	-

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
55000	-	4 * 55000, SDS-PAGE	Leishmania donovani
204000	-	gel filtration	Leishmania donovani

Organism

Organism	UniProt	Comment	Textmining
Leishmania donovani	-	-	-

Storage Stability

Storage Stability	Organism
-80°C, purified protein remains active for more than 18 months	Leishmania donovani

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
inosine 5'-phosphate + NAD+ + H2O	enzyme is highly specific for both inosine 5'-phosphate and NAD+	Leishmania donovani	xanthosine 5'-phosphate + NADH	-	?

Subunits

Subunits	Comment	Organism
More	IMPDH associates tightly with glycosomal protein sorting receptor PEX5	Leishmania donovani
tetramer	4 * 55000, SDS-PAGE	Leishmania donovani

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.000025	-	Mycophenolic acid	pH 7.5, 25°C	Leishmania donovani
0.026	-	XMP	pH 7.5, 25°C	Leishmania donovani
0.21	-	GMP	pH 7.5, 25°C	Leishmania donovani

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Release 2023.1 (January 2023)