Literature summary for 1.1.1.205 extracted from

Sanquer, S.; Maison, P.; Tomkiewicz, C.; Macquin-Mavier, I.; Legendre, C.; Barouki, R.; Lang, P.
Expression of inosine monophosphate dehydrogenase type I and type II after mycophenolate mofetil treatment: a 2-year follow-up in kidney transplantation (2008), Clin. Pharmacol. Ther., 83, 328-335.

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Application

Application	Comment	Organism
medicine	in patients with kidney transplantation, type I IMPDH activity and gene expression increases during the first three months following transplantation and reaches its maximal level during acute rejection episodes, whereas type II mRNA is stable. Patients with a prolonged mycophenolate mofetil treatment exhibit an increase in the induction potency of both IMPDH activity and gene expression. Measurement of IMPDH mRNAs may provide reliable information to predict acute rejection	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	patients with kidney transplantation	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
blood	whole blood	Homo sapiens	-
mononuclear cell	-	Homo sapiens	-

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Release 2023.1 (January 2023)