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Literature summary for 1.1.1.205 extracted from
- Rajagopalan KV, Handler P: Purification and properties of inosinic acid dehydrogenase from Escherichia coli (1969), J. Biol. Chem., 244, 4793-4797.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| glutathione | - |
Escherichia coli |  |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| ADP | - |
Escherichia coli | |
| AMP | - |
Escherichia coli | |
| ATP | - |
Escherichia coli | |
| GDP | - |
Escherichia coli | |
| GMP | - |
Escherichia coli | |
| GTP | - |
Escherichia coli | |
| Mg2+ | inhibits K+ activation | Escherichia coli | |
| p-chloromercuribenzoate | - |
Escherichia coli | |
| xanthosine 5'-phosphate | - |
Escherichia coli | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| K+ | activation | Escherichia coli | |
| Na+ | no effect | Escherichia coli | |
| NH4+ | activation | Escherichia coli | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| additional information | - |
various molecular species | Escherichia coli |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Escherichia coli | - |
derepressed mutant | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| derepressed mutant | Escherichia coli |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
- |
Escherichia coli |
Storage Stability
| Storage Stability | Organism |
|---|---|
| -17°C, 24 h, 10% loss of activity | Escherichia coli |
| 4°C, 24 h, 13% loss of activity | Escherichia coli |
| frozen in 5 mM mercaptoethanol, 3 months, 50% loss of activity | Escherichia coli |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| inosine 5'-phosphate + NAD+ + H2O | - |
Escherichia coli | xanthosine 5'-phosphate + NADH | - |
ir | |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 25 | - |
assay at | Escherichia coli |
Temperature Stability [°C]
| Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 4 | - |
13% loss of activity within 1 day | Escherichia coli |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| acetylpyridine-NAD+ | 60% as effective as NAD+ | Escherichia coli | |
| NAD+ | - |
Escherichia coli | |
| NADP+ | not | Escherichia coli | |
| thionicotinamide-NAD+ | 5% as effective as NAD+ | Escherichia coli | |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | inhibition by purine nucleotides | Escherichia coli |
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